The effectiveness of sublingual immunotherapy for house dust mite-induced allergic rhinitis and its co-morbid conditions

被引：9

作者：

Chan, Alson Wai-ming ^{[1
]}

Luk, Wing Pan ^{[2
]}

Fung, Ling Hiu ^{[2
]}

Lee, Tak Hong ^{[1
]}

机构：

[1] Hong Kong Sanat & Hosp, Allergy Ctr, Happy Valley, 2 Village Rd, Hong Kong, Peoples R China

[2] Hong Kong Sanat & Hosp, Med Phys & Res Dept, Happy Valley, 2 Village Rd, Hong Kong, Peoples R China

来源：

IMMUNOTHERAPY | 2019年 / 11卷 / 16期

关键词：

allergic rhinitis; asthma; atopic dermatitis; conjunctivitis; eczema; effectiveness; immunotherapy; mite; sublingual; SYMPTOMATIC TREATMENT; ECONOMIC-EVALUATION; ATOPIC-DERMATITIS; CONTROLLED-TRIALS; ASTHMA; RHINOCONJUNCTIVITIS; SENSITIZATIONS; ORGANIZATION; PREVALENCE; CHILDREN;

D O I：

10.2217/imt-2019-0093

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aim: We investigated sublingual immunotherapy for mite-induced allergic rhinitis and its comorbid allergic conditions. Patients & methods: A prospective case-controlled study of 120 patients (case = 80, control = 40) over 12 months. Results: There was 53.6% reduction in total rhinitis symptom score (p < 0.0001), but not in controls (-7.3%, p = 0.99). The total symptom scores for concurrent asthma decreased from 17.79 to 8.8 (p < 0.0001); for allergic conjunctivitis from 20.89 to 10.0 (p = 0.0002); for atopic dermatitis from 46.40 to 29.38 (p = 0.0004) and 74.6% of patients weaned off nasal topical steroids. The treatment-related adverse reactions were mild and self-limiting. Conclusion: Though sublingual immunotherapy may be more expensive than conventional treatments, it was an adjunctive therapy that improved not only the outcomes for allergic rhinitis, but also its comorbid allergic conditions.

引用

页码：1387 / 1397

页数：11

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