Toward Hyperpolarized 19F Molecular Imaging via Reversible Exchange with Parahydrogen

被引：63

作者：

Shchepin, Roman V. ^{[1
]}

Goodson, Boyd M. ^{[2
]}

Theis, Thomas ^{[3
]}

Warren, Warren S. ^{[3
]}

Chekmenev, Eduard Y. ^{[1
,4
]}

机构：

[1] Vanderbilt Univ, Inst Imaging Sci, Vanderbilt Ingram Canc Ctr, Dept Radiol,Dept Biomed Engn,Dept Phys, Nashville, TN 37232 USA

[2] Southern Illinois Univ, Dept Chem & Biochem, Mat Technol Ctr, Carbondale, IL 62901 USA

[3] Duke Univ, Dept Chem, 124 Sci Dr, Durham, NC 27708 USA

[4] Russian Acad Sci, Leninskiy Prospekt 14, Moscow 119991, Russia

来源：

CHEMPHYSCHEM | 2017年 / 18卷 / 15期

基金：

美国国家科学基金会;

关键词：

fluorine-19; hyperpolarization; molecular imaging; MRI; parahydrogen; NMR SIGNAL AMPLIFICATION; NUCLEAR-SPIN STATES; LONG-LIVED STATES; MAGNETIC-RESONANCE; IN-VIVO; N-15; HYPERPOLARIZATION; INDUCED POLARIZATION; PARA-HYDROGEN; SABRE; C-13;

D O I：

10.1002/cphc.201700594

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Fluorine-19 has high NMR detection sensitivity-similar to that of protons-owing to its large gyromagnetic ratio and high natural abundance (100 %). Unlike protons, however, fluorine-19 (F-19) has a negligible occurrence in biological objects, as well as a more sensitive chemical shift. As a result, in vivo F-19 NMR spectroscopy and MR imaging offer advantages of negligible background signal and sensitive reporting of the local molecular environment. Here we report on NMR hyperpolarization of 19F nuclei using reversible exchange reactions with parahydrogen gas as the source of nuclear spin order. NMR signals of 3-fluoropyridine were enhanced by approximate to 100 fold, corresponding to 0.3% F-19 nuclear spin polarization (at 9.4 T), using about 50% parahydrogen. While future optimization efforts will likely significantly increase the hyperpolarization levels, we already demonstrate the utility of F-19 hyperpolarization for high-resolution hyperpolarized F-19 imaging and hyperpolarized F-19 pH sensing.

引用

页码：1961 / 1965

页数：5