Long Non-coding RNA MAFG-AS1 Promotes Cell Proliferation, Migration, and EMT by miR-3196/STRN4 in Drug-Resistant Cells of Liver Cancer

被引：24
作者：
Chen, Tianming [1 ]
Huang, Bin [2 ,3 ]
Pan, Yaozhen [4 ]
机构：
[1] Nanjing Univ, Med Sch, Drum Tower Hosp, Dept Surg, Nanjing, Peoples R China
[2] Nanjing Univ, Med Sch, Affiliated Hosp, Nanjing Drum Tower Hosp,Comprehens Canc Ctr, Nanjing, Peoples R China
[3] Nanjing Univ, Clin Canc Inst, Nanjing, Peoples R China
[4] Guizhou Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Guiyang, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷
关键词：
long non-coding RNA; MAFG-AS1; miR-3196; STRN4; liver cancer; EPITHELIAL-MESENCHYMAL TRANSITION; HEPATOCELLULAR-CARCINOMA; INVASION; GROWTH;
D O I：
10.3389/fcell.2021.688603
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Long non-coding RNAs (lncRNAs) have been shown to participate in the development and progression of several different types of cancer. Past studies indicated that lncRNA MAFG-antisense 1 (AS1) promotes colorectal cancer. However, the role of MAFG-AS1 in hepatocellular carcinoma (HCC) remains unclear. The aim of the present study is to examine the effect of lncRNA MAFG-AS1 on drug resistance HCC. The results indicated that MAFG-AS1 is upregulated in drug-resistant cells. Further, MAFG-AS1 promotes growth and migration of HCC by upregulating STRN4 through absorbing miR-3196. Thus, LncRNA MAFA-AS1 may become a novel target to treat HCC patients.
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页数：10
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