What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology

被引：12

作者：

Altulea, Dania ^{[1
]}

Maassen, Sjors ^{[1
]}

Baranov, Maksim, V ^{[1
]}

van den Bogaart, G. ^{[1
,2
]}

机构：

[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Immunol & Microbiol, Groningen, Netherlands

[2] Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Dept Tumor Immunol, Med Ctr, Nijmegen, Netherlands

来源：

JOURNAL OF MOLECULAR CELL BIOLOGY | 2021年 / 13卷 / 03期

基金：

欧洲研究理事会;

关键词：

coronavirus; COVID-19; SARS-CoV-2; chloroquine; hydroxychloroquine; RESPIRATORY SYNDROME CORONAVIRUS; LIPID RAFTS; CHLOROQUINE; HYDROXYCHLOROQUINE; INHIBITION; INFECTION; AUTOPHAGY; MACROPHAGES; ACTIVATION; MECHANISMS;

D O I：

10.1093/jmcb/mjab016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease (COVID-19). However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.

引用

页码：175 / 184

页数：10

共 94 条

[81] Chloroquine is a potent inhibitor of SARS coronavirus infection and spread [J].

Vincent, Martin J. ;

Bergeron, Eric ;

Benjannet, Suzanne ;

Erickson, Bobbie R. ;

Rollin, Pierre E. ;

Ksiazek, Thomas G. ;

Seidah, Nabil G. ;

Nichol, Stuart T. .

VIROLOGY JOURNAL, 2005, 2 (1)

[82]

Walls AC, 2020, CELL, V181, P281, DOI [10.1016/j.cell.2020.02.058, 10.1016/j.cell.2020.11.032]

[83] Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro [J].

Wang, Manli ;

Cao, Ruiyuan ;

Zhang, Leike ;

Yang, Xinglou ;

Liu, Jia ;

Xu, Mingyue ;

Shi, Zhengli ;

Hu, Zhihong ;

Zhong, Wu ;

Xiao, Gengfu .

CELL RESEARCH, 2020, 30 (03) :269-271

[84] Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus [J].

Wang, Nan ;

Han, Shengli ;

Liu, Rui ;

Meng, Liesu ;

He, Huaizhen ;

Zhang, Yongjing ;

Wang, Cheng ;

Lv, Yanni ;

Wang, Jue ;

Li, Xiaowei ;

Ding, Yuanyuan ;

Fu, Jia ;

Hou, Yajing ;

Lu, Wen ;

Ma, Weina ;

Zhan, Yingzhuan ;

Dai, Bingling ;

Zhang, Jie ;

Pan, Xiaoyan ;

Hu, Shiling ;

Gao, Jiapan ;

Jia, Qianqian ;

Zhang, Liyang ;

Ge, Shuai ;

Wang, Saisai ;

Liang, Peida ;

Hu, Tian ;

Lu, Jiayu ;

Wang, Xiangjun ;

Zhou, Huaxin ;

Ta, Wenjing ;

Wang, Yuejin ;

Lu, Shemin ;

He, Langchong .

PHYTOMEDICINE, 2020, 79

[85] Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 In Vitro and SARS-CoV In Vivo [J].

Weston, Stuart ;

Coleman, Christopher M. ;

Haupt, Robert ;

Logue, James ;

Matthews, Krystal ;

Li, Yize ;

Reyes, Hanako M. ;

Weiss, Susan R. ;

Frieman, Matthew B. .

JOURNAL OF VIROLOGY, 2020, 94 (21)

[86] Repurposed Antiviral Drugs for Covid-19-Interim WHO Solidarity Trial Results [J].

Pan H. ;

Peto R. ;

Henao‑Restrepo A.-M. ;

Preziosi M.-P. ;

Sathiyamoorthy V. ;

Karim Q.A. ;

Alejandria M.M. ;

García C.H. ;

Kieny M.-P. ;

Malekzadeh R. ;

Murthy S. ;

Srinath Reddy K. ;

Periago M.R. ;

Hanna P.A. ;

Ader F. ;

Al‑Bader A.M. ;

Alhasawi A. ;

Allum E. ;

Alotaibi A. ;

Alvarez‑Moreno C.A. ;

Appadoo S. ;

Asiri A. ;

Aukrust P. ;

Barratt‑Due A. ;

Bellani S. ;

Branca M. ;

Cappel‑Porter H.B.C. ;

Cerrato N. ;

Chow T.S. ;

Como N. ;

Eustace J. ;

García P.J. ;

Godbole S. ;

Gotuzzo E. ;

Griskevicius L. ;

Hamra R. ;

Hassan M. ;

Hassany M. ;

Hutton D. ;

Irmansyah I. ;

Jancoriene L. ;

Kirwan J. ;

Kumar S. ;

Lennon P. ;

Lopardo G. ;

Lydon P. ;

Magrini N. ;

Maguire T. ;

Manevska S. ;

Manuel O. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (06) :497-511

[87] A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery [J].

Wolfram, Joy ;

Nizzero, Sara ;

Liu, Haoran ;

Li, Feng ;

Zhang, Guodong ;

Li, Zheng ;

Shen, Haifa ;

Blanco, Elvin ;

Ferrari, Mauro .

SCIENTIFIC REPORTS, 2017, 7

[88] Chloroquine Is a Zinc Ionophore [J].

Xue, Jing ;

Moyer, Amanda ;

Peng, Bing ;

Wu, Jinchang ;

Hannafon, Bethany N. ;

Ding, Wei-Qun .

PLOS ONE, 2014, 9 (10)

[89] Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19 [J].

Yang, Naidi ;

Shen, Han-Ming .

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2020, 16 (10) :1724-1731

[90] In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) [J].

Yao, Xueting ;

Ye, Fei ;

Zhang, Miao ;

Cui, Cheng ;

Huang, Baoying ;

Niu, Peihua ;

Liu, Xu ;

Zhao, Li ;

Dong, Erdan ;

Song, Chunli ;

Zhan, Siyan ;

Lu, Roujian ;

Li, Haiyan ;

Tan, Wenjie ;

Liu, Dongyang .

CLINICAL INFECTIOUS DISEASES, 2020, 71 (15) :732-739

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