What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology

被引：12

作者：

Altulea, Dania ^{[1
]}

Maassen, Sjors ^{[1
]}

Baranov, Maksim, V ^{[1
]}

van den Bogaart, G. ^{[1
,2
]}

机构：

[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Immunol & Microbiol, Groningen, Netherlands

[2] Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Dept Tumor Immunol, Med Ctr, Nijmegen, Netherlands

来源：

JOURNAL OF MOLECULAR CELL BIOLOGY | 2021年 / 13卷 / 03期

基金：

欧洲研究理事会;

关键词：

coronavirus; COVID-19; SARS-CoV-2; chloroquine; hydroxychloroquine; RESPIRATORY SYNDROME CORONAVIRUS; LIPID RAFTS; CHLOROQUINE; HYDROXYCHLOROQUINE; INHIBITION; INFECTION; AUTOPHAGY; MACROPHAGES; ACTIVATION; MECHANISMS;

D O I：

10.1093/jmcb/mjab016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease (COVID-19). However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.

引用

页码：175 / 184

页数：10

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