What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology

被引：12
作者：
Altulea, Dania [1 ]
Maassen, Sjors [1 ]
Baranov, Maksim, V [1 ]
van den Bogaart, G. [1 ,2 ]
机构：
[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Immunol & Microbiol, Groningen, Netherlands
[2] Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Dept Tumor Immunol, Med Ctr, Nijmegen, Netherlands
来源：
JOURNAL OF MOLECULAR CELL BIOLOGY | 2021年 / 13卷 / 03期
基金：
欧洲研究理事会;
关键词：
coronavirus; COVID-19; SARS-CoV-2; chloroquine; hydroxychloroquine; RESPIRATORY SYNDROME CORONAVIRUS; LIPID RAFTS; CHLOROQUINE; HYDROXYCHLOROQUINE; INHIBITION; INFECTION; AUTOPHAGY; MACROPHAGES; ACTIVATION; MECHANISMS;
D O I：
10.1093/jmcb/mjab016
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease (COVID-19). However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.
引用
收藏
页码：175 / 184
页数：10
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