A receptor subtype involved in neuropeptide-Y-induced food intake

被引：812

作者：

Gerald, C ^{[1
]}

Walker, MW ^{[1
]}

Criscione, L ^{[1
]}

Gustafson, EL ^{[1
]}

BatzlHartmann, C ^{[1
]}

Smith, KE ^{[1
]}

Vaysse, P ^{[1
]}

Durkin, MM ^{[1
]}

Laz, TM ^{[1
]}

Linemeyer, DL ^{[1
]}

Schaffhauser, AO ^{[1
]}

Whitebread, S ^{[1
]}

Hofbauer, KG ^{[1
]}

Taber, RI ^{[1
]}

Branchek, TA ^{[1
]}

Weinshank, RL ^{[1
]}

机构：

[1] CIBA GEIGY LTD,DIV PHARMACEUT,METAB RISK FACTOR DEPT,CH-4002 BASEL,SWITZERLAND

来源：

NATURE | 1996年 / 382卷 / 6587期

关键词：

D O I：

10.1038/382168a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

NEUROPEPTIDE Y (NPY) is a powerful stimulant of food intake and is proposed to activate a hypothalamic 'feeding' receptor distinct from previously cloned Y-type receptors(1). This receptor was first suggested to explain a feeding response to NPY and related peptides, including NPY2-36, that differed from their activities at the Y1 receptor(2), Here we report the expression cloning of a novel Y-type receptor from rat hypothalamus, which we name Y5, The complementary DNA encodes a 456-amino-acid protein with less than 35% overall identity to known Y-type receptors, The messenger RNA is found primarily in the central nervous system, including the paraventricular nucleus of the hypothalamus. The extent to which selected peptides can Inhibit adenylate cyclase through the Y5 receptor and stimulate food intake in rats correspond well, Our data support the idea that the Y5 receptor is the postulated 'feeding' receptor, and may provide a new method for the study and treatment of obesity and eating disorders.

引用

页码：168 / 171

页数：4

共 28 条

[1]

[Anonymous], 1993, BIOL NEUROPEPTIDE RE, DOI DOI 10.1007/978-1-59259-465-8_11

[2] [D-TRP(32)]NEUROPEPTIDE-Y - A COMPETITIVE ANTAGONIST OF NPY IN RAT HYPOTHALAMUS [J].

BALASUBRAMANIAM, A ;

SHERIFF, S ;

JOHNSON, ME ;

PRABHAKARAN, M ;

HUANG, Y ;

FISCHER, JE ;

CHANCE, WT .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (06) :811-815

[3] MULTIPLE PROMOTERS REGULATE TISSUE-SPECIFIC EXPRESSION OF THE HUMAN NPY-Y1 RECEPTOR GENE [J].

BALL, HJ ;

SHINE, J ;

HERZOG, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (45) :27272-27276

[4] CLONING AND FUNCTIONAL EXPRESSION OF A HUMAN Y4 SUBTYPE RECEPTOR FOR PANCREATIC-POLYPEPTIDE, NEUROPEPTIDE-Y, AND PEPTIDE YY [J].

BARD, JA ;

WALKER, MW ;

BRANCHEK, TA ;

WEINSHANK, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (45) :26762-26765

[5]

BARD JA, 1995, Patent No. 17906

[6] CLONING AND SEQUENCE-ANALYSIS OF A NEUROPEPTIDE-Y PEPTIDE YY RECEPTOR Y1 CDNA FROM XENOPUS-LAEVIS [J].

BLOMQVIST, AG ;

ROUBOS, EW ;

LARHAMMAR, D ;

MARTENS, GJM .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1995, 1261 (03) :439-441

[7] FUNCTIONAL-CHARACTERIZATION OF RECEPTORS WITH AFFINITY FOR PYY, NPY, [LEU(31),PRO(34)]NPY AND PP IN A HUMAN COLONIC EPITHELIAL-CELL LINE [J].

COX, HM ;

TOUGH, IR .

BRITISH JOURNAL OF PHARMACOLOGY, 1995, 116 (06) :2673-2678

[8] LOCALIZATION OF MESSENGER-RNAS ENCODING 3 GABA TRANSPORTERS IN RAT-BRAIN - AN IN-SITU HYBRIDIZATION STUDY [J].

DURKIN, MM ;

SMITH, KE ;

BORDEN, LA ;

WEINSHANK, RL ;

BRANCHEK, TA ;

GUSTAFSON, EL .

MOLECULAR BRAIN RESEARCH, 1995, 33 (01) :7-21

[9] THE MURINE NPY-1 RECEPTOR GENE - STRUCTURE AND DELINEATION OF TISSUE-SPECIFIC EXPRESSION [J].

EVA, C ;

OBERTO, A ;

SPRENGEL, R ;

GENAZZANI, E .

FEBS LETTERS, 1992, 314 (03) :285-288

[10] MOLECULAR-CLONING OF A NOVEL-G PROTEIN-COUPLED RECEPTOR THAT MAY BELONG TO THE NEUROPEPTIDE RECEPTOR FAMILY [J].

EVA, C ;

KEINANEN, K ;

MONYER, H ;

SEEBURG, P ;

SPRENGEL, R .

FEBS LETTERS, 1990, 271 (1-2) :81-84

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