IL-7 in SARS-CoV-2 Infection and as a Potential Vaccine Adjuvant

被引：28

作者：

Bekele, Yonas ^{[1
]}

Sui, Yongjun ^{[1
]}

Berzofsky, Jay A. ^{[1
]}

机构：

[1] NCI, Vaccine Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

关键词：

IL-7; IL-7R; SARS-CoV-2; COVID-19; adjuvant; CD8(+) T-CELLS; INTERLEUKIN-7; NAIVE; EXPRESSION; CYTOKINE; SURVIVAL; DIFFERENTIATION; PROLIFERATION; ACTIVATION; EXPANSION;

D O I：

10.3389/fimmu.2021.737406

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-7/IL-7R signaling is critical for development, maturation, maintenance and survival of many lymphocytes in the thymus and periphery. IL-7 has been used as immunotherapy in pre-clinical and clinical studies to treat cancer, HIV infection and sepsis. Here, we discuss the critical function of IL-7 in diagnosis, prognosis and treatment of COVID-19 patients. We also summarize a promising role of IL-7 as a vaccine adjuvant. It could potentially enhance the immune responses to vaccines especially against SARS-CoV-2 or other new vaccines.

引用

页数：6

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