Cascade Coupling/Cyclization process to n-substituted 1,3-dihydrobenzimidazol-2-ones

被引：85

作者：

Zou, Benli

Yuan, Offlang

Ma, Dawei ^{[1
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan, Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 21期

关键词：

D O I：

10.1021/ol701792j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Assembly of N-substituted 1,3-dihydrobenzimidazol-2-ones is achieved starting from methyl o-haloarylcarbamates via a Cul/amino acid catalyzed coupling with amines and subsequent condensative cyclization. A number of functional groups are tolerated by these reaction conditions, including vinyl, nitro, carboxylate, amide, ester, ketone, and silyl ether groups.

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页码：4291 / 4294

页数：4

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