Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

被引：47

作者：

Jardim, Guilherme A. M. ^{[1
]}

Guimaraes, Tiago T. ^{[2
]}

Pinto, Maria do Carmo F. R. ^{[3
]}

Cavalcanti, Bruno C. ^{[4
]}

de Farias, Kaio M. ^{[4
]}

Pessoa, Claudia ^{[4
]}

Gatto, Claudia C. ^{[5
]}

Nair, Divya K. ^{[6
]}

Namboothiri, Irishi N. N. ^{[6
]}

da Silva Junior, Eufranio N. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Chem, Inst Exact Sci, BR-31270901 Belo Horizonte, MG, Brazil

[2] Hosp Canc, Inst Nacl Canc, Unidade 1, Secao Med Nucl, BR-20230130 Rio De Janeiro, RJ, Brazil

[3] Univ Fed Rio de Janeiro, Nucleo Pesquisas Prod Nat, BR-21944971 Rio de Janeiro, RJ, Brazil

[4] Univ Fed Ceara, Dept Fisiol & Farmacol, BR-60430270 Fortaleza, CE, Brazil

[5] Fiocruz Ceara, BR-60180900 Fortaleza, CE, Brazil

[6] Univ Brasilia, Inst Chem, BR-70904970 Brasilia, DF, Brazil

来源：

MEDCHEMCOMM | 2015年 / 6卷 / 01期

关键词：

NOR-BETA-LAPACHONE; ALPHA-LAPACHONE; HETEROCYCLIC-DERIVATIVES; ANTITUMOR-ACTIVITY; TRYPANOSOMA-CRUZI; CYTOTOXICITY; ARYLAMINO; SURVIVAL; DESIGN; AGENTS;

D O I：

10.1039/c4md00371c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel naphthoquinone-based chalcones were prepared from the reaction between 3-bromo-nor-beta-lapachone and amino-chalcones. Lapachone derivatives are also described here. All the substances were evaluated against cancer and normal cell lines and several compounds demonstrated potent antitumor activity.

引用

页码：120 / 130

页数：11

共 47 条

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