Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

被引：47
作者：
Jardim, Guilherme A. M. [1 ]
Guimaraes, Tiago T. [2 ]
Pinto, Maria do Carmo F. R. [3 ]
Cavalcanti, Bruno C. [4 ]
de Farias, Kaio M. [4 ]
Pessoa, Claudia [4 ]
Gatto, Claudia C. [5 ]
Nair, Divya K. [6 ]
Namboothiri, Irishi N. N. [6 ]
da Silva Junior, Eufranio N. [1 ]
机构：
[1] Univ Fed Minas Gerais, Dept Chem, Inst Exact Sci, BR-31270901 Belo Horizonte, MG, Brazil
[2] Hosp Canc, Inst Nacl Canc, Unidade 1, Secao Med Nucl, BR-20230130 Rio De Janeiro, RJ, Brazil
[3] Univ Fed Rio de Janeiro, Nucleo Pesquisas Prod Nat, BR-21944971 Rio de Janeiro, RJ, Brazil
[4] Univ Fed Ceara, Dept Fisiol & Farmacol, BR-60430270 Fortaleza, CE, Brazil
[5] Fiocruz Ceara, BR-60180900 Fortaleza, CE, Brazil
[6] Univ Brasilia, Inst Chem, BR-70904970 Brasilia, DF, Brazil
来源：
MEDCHEMCOMM | 2015年 / 6卷 / 01期
关键词：
NOR-BETA-LAPACHONE; ALPHA-LAPACHONE; HETEROCYCLIC-DERIVATIVES; ANTITUMOR-ACTIVITY; TRYPANOSOMA-CRUZI; CYTOTOXICITY; ARYLAMINO; SURVIVAL; DESIGN; AGENTS;
D O I：
10.1039/c4md00371c
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Novel naphthoquinone-based chalcones were prepared from the reaction between 3-bromo-nor-beta-lapachone and amino-chalcones. Lapachone derivatives are also described here. All the substances were evaluated against cancer and normal cell lines and several compounds demonstrated potent antitumor activity.
引用
收藏
页码：120 / 130
页数：11
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