Laser electrospray mass spectrometry of adsorbed molecules at atmospheric pressure

被引：3

作者：

Brady, John J. ^{[1
]}

Judge, Elizabeth J. ^{[1
]}

Simon, Kuriakose ^{[1
]}

Levis, Robert J. ^{[1
]}

机构：

[1] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA

来源：

IMAGING, MANIPULATION, AND ANALYSIS OF BIOMOLECULES, CELLS, AND TISSUES VIII | 2010年 / 7568卷

关键词：

femtosecond; mass spectrometry; electrospray; vaporization; LEMS; non-resonant; laser; MULTILAYER BENZENE; AMBIENT CONDITIONS; AQUEOUS-SOLUTION; IONIZATION; DESORPTION; FEMTOSECOND; ABLATION; DESI; METABOLITES; EXPLOSIVES;

D O I：

10.1117/12.842217

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Atmospheric pressure mass analysis of solid phase biomolecules is performed using laser electrospray mass spectrometry (LEMS). A non-resonant femtosecond duration laser pulse vaporizes native samples at atmospheric pressure for subsequent electrospray ionization and transfer into a mass spectrometer. LEMS was used to detect a complex molecule (irinotecan HCl), a complex mixture (cold medicine formulation with active ingredients: acetaminophen, dextromethorphan HBr and doxylamine succinate), and a biological building block (deoxyguanosine) deposited on steel surfaces without a matrix molecule.

引用

收藏

页数：8

相关论文

共 40 条

[21] FRAGMENTATION OF VITAMIN-B-12 DURING 337 NM MATRIX-ASSISTED LASER-DESORPTION IONIZATION [J].

KINSEL, GR ;

PRESTON, LM ;

RUSSELL, DH .

BIOLOGICAL MASS SPECTROMETRY, 1994, 23 (04) :205-211

[22] Using electrospray-assisted laser desorption/ionization mass spectrometry to characterize organic compounds separated on thin-layer chromatography plates [J].

Lin, Shu-Yao ;

Huang, Min-Zong ;

Chang, Hui-Chiu ;

Shiea, Jentaie .

ANALYTICAL CHEMISTRY, 2007, 79 (22) :8789-8795

[23] Direct Analysis of Liquid Samples by Desorption Electrospray Ionization-Mass Spectrometry (DESI-MS) [J].

Miao, Zhixin ;

Chen, Hao .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2009, 20 (01) :10-19

[24] Ambient molecular imaging and depth profiling of live tissue by infrared laser ablation electrospray ionization mass spectrometry [J].

Nemes, Peter ;

Barton, Alexis A. ;

Li, Yue ;

Vertes, Akos .

ANALYTICAL CHEMISTRY, 2008, 80 (12) :4575-4582

[25] Laser ablation electrospray ionization for atmospheric pressure, in vivo, and imaging mass spectrometry [J].

Nemes, Peter ;

Vertes, Akos .

ANALYTICAL CHEMISTRY, 2007, 79 (21) :8098-8106

[26] Three-Dimensional Imaging of Metabolites in Tissues under Ambient Conditions by Laser Ablation Electrospray Ionization Mass Spectrometry [J].

Nemes, Peter ;

Barton, Alexis A. ;

Vertes, Akos .

ANALYTICAL CHEMISTRY, 2009, 81 (16) :6668-6675

[27] MATRIX-ASSISTED LASER DESORPTION IONIZATION MASS-SPECTROMETRY OF NUCLEIC-ACIDS WITH WAVELENGTHS IN THE ULTRAVIOLET AND INFRARED [J].

NORDHOFF, E ;

INGENDOH, A ;

CRAMER, R ;

OVERBERG, A ;

STAHL, B ;

KARAS, M ;

HILLENKAMP, F ;

CRAIN, PF .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1992, 6 (12) :771-776

[28] LASER-PULSE SPUTTERING OF ALUMINUM - VAPORIZATION, BOILING, SUPERHEATING, AND GAS-DYNAMIC EFFECTS [J].

PETERLONGO, A ;

MIOTELLO, A ;

KELLY, R .

PHYSICAL REVIEW E, 1994, 50 (06) :4716-4727

[29] DESORPTION INDUCED BY FEMTOSECOND LASER-PULSES [J].

PRYBYLA, JA ;

HEINZ, TF ;

MISEWICH, JA ;

LOY, MMT ;

GLOWNIA, JH .

PHYSICAL REVIEW LETTERS, 1990, 64 (13) :1537-1540

[30] Direct characterization of intact polypeptides by matrix-assisted laser desorption electrospray ionization quadrupole Fourier transform ion cyclotron resonance mass spectrometry [J].

Sampson, Jason S. ;

Hawkridge, Adam M. ;

Muddiman, David C. .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2007, 21 (07) :1150-1154

← 1 2 3 4 →