Laser electrospray mass spectrometry of adsorbed molecules at atmospheric pressure

被引：3

作者：

Brady, John J. ^{[1
]}

Judge, Elizabeth J. ^{[1
]}

Simon, Kuriakose ^{[1
]}

Levis, Robert J. ^{[1
]}

机构：

[1] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA

来源：

IMAGING, MANIPULATION, AND ANALYSIS OF BIOMOLECULES, CELLS, AND TISSUES VIII | 2010年 / 7568卷

关键词：

femtosecond; mass spectrometry; electrospray; vaporization; LEMS; non-resonant; laser; MULTILAYER BENZENE; AMBIENT CONDITIONS; AQUEOUS-SOLUTION; IONIZATION; DESORPTION; FEMTOSECOND; ABLATION; DESI; METABOLITES; EXPLOSIVES;

D O I：

10.1117/12.842217

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Atmospheric pressure mass analysis of solid phase biomolecules is performed using laser electrospray mass spectrometry (LEMS). A non-resonant femtosecond duration laser pulse vaporizes native samples at atmospheric pressure for subsequent electrospray ionization and transfer into a mass spectrometer. LEMS was used to detect a complex molecule (irinotecan HCl), a complex mixture (cold medicine formulation with active ingredients: acetaminophen, dextromethorphan HBr and doxylamine succinate), and a biological building block (deoxyguanosine) deposited on steel surfaces without a matrix molecule.

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页数：8

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