Nickel-Catalyzed Cascade Reactions

The formation of molecules with complexity in a simple, straight forward pathway attracts great interest in organic synthesis. Recently, nickel-catalyzed cascade reactions have grown up as a useful tool and contributed significantly to the area of synthetic methodology. In order to furnish high yielding carbo- and heterocycles as building blocks of pharmaceutical compounds and bioactive molecules with high selectivity, nickel-catalyzed reactions render comprehensive coverage of different strategies through compilation of various methodological prospective, such as photoredox decarboxylative vinylation, asymmetric reductive arylalkynation, hydroacylation/ Suzuki cross-coupling reactions, intramolecular annulation cascade reactions, hemiacetalization cascade reactions, and so on. In addition, nickel-catalyzed cascade reactions are also useful for the synthesis of multiple C-C/C-N bonds in acyclic compounds. This Review provides in depth mechanistic insights into on crucial reactions as well as a detailed discussion and critical comments.