HAV infection in chronic liver disease: a rationale for vaccination

被引：37

作者：

Almasio, PL

Amoroso, P

机构：

[1] Univ Palermo, Cattedra Gastroenterol, Med Clin 1, I-90127 Palermo, Italy

[2] Azienda Osped Domenico Cotugno, Naples, Italy

来源：

VACCINE | 2003年 / 21卷 / 19-20期

关键词：

HAV infections; chronic liver disease; vaccination;

D O I：

10.1016/S0264-410X(03)00139-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report the conduct and results of a systematic search of the literature to assess whether exposure to HAV could induce a fatal deterioration of liver diseases. We assessed 30 studies and found evidence of progressive decrease of natural immunity against HAV in Italy. HAV vaccine seems as safe in chronic liver diseases than in general population. On the basis of the evidence we recommend that subjects with chronic liver disease should be vaccinated against HAV, especially if younger than 40 years. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2238 / 2241

页数：4

共 36 条

[1] FULMINANT HEPATITIS-A IN INTRAVENOUS DRUG-USERS WITH CHRONIC LIVER-DISEASE [J].