Genomic microarrays: a technology overview

被引：49

作者：

Brady, Paul D. ^{[1
]}

Vermeesch, Joris R. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Univ Hosp Leuven, Ctr Human Genet, Lab Cytogenet & Genome Res, Louvain, Belgium

来源：

PRENATAL DIAGNOSIS | 2012年 / 32卷 / 04期

关键词：

Array CGH; General cytogenetics; DNA; Copy Number Variation; SNP array; Genomic Arrays; CONGENITAL DIAPHRAGMATIC-HERNIA; RAPID PRENATAL-DIAGNOSIS; IN-SITU HYBRIDIZATION; COPY NUMBER VARIATION; FREE FETAL DNA; BALANCED CHROMOSOME REARRANGEMENTS; CONSTITUTIONAL GENETIC DIAGNOSIS; SINGLE-NUCLEOTIDE POLYMORPHISMS; IDIOPATHIC MENTAL-RETARDATION; LOW-LEVEL MOSAICISM;

D O I：

10.1002/pd.2933

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genomic microarrays are now widely used diagnostically for the molecular karyotyping of patients with intellectual disability, congenital anomalies and autistic spectrum disorder and have more recently been applied for the detection of genomic imbalances in prenatal genetic diagnosis. We present an overview of the different arrays, protocols used and discuss methods of genomic array data analysis. (C) 2012 John Wiley & Sons, Ltd.

引用

页码：336 / 343

页数：8

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