Activation of Local Inhibitory Circuits in the Dentate Gyrus by Adult-Born Neurons

被引：116

作者：

Drew, Liam J. ^{[1
,2
,9
]}

Kheirbek, Mazen A. ^{[1
,2
,3
]}

Luna, Victor M. ^{[1
,2
]}

Denny, Christine A. ^{[1
,2
]}

Cloidt, Megan A. ^{[2
]}

Wu, Melody V. ^{[1
,2
,10
]}

Jain, Swati ^{[4
]}

Scharfman, Helen E. ^{[4
,5
,6
,7
]}

Hen, Rene ^{[1
,2
,3
,8
]}

机构：

[1] Columbia Univ, Dept Psychiat, New York, NY USA

[2] New York State Psychiat Inst & Hosp, Div Integrat Neurosci, New York, NY 10032 USA

[3] Columbia Univ, Dept Neurosci, New York, NY USA

[4] Nathan S Kline Inst Psychiat Res, Ctr Dementia Res, 140 Old Orangeburg Rd,Bldg 35, Orangeburg, NY USA

[5] NYU, Dept Child & Adolescent Psychiat, Langone Med Ctr, New York, NY USA

[6] NYU, Dept Physiol & Neurosci, Langone Med Ctr, New York, NY USA

[7] NYU, Dept Psychiat, Langone Med Ctr, 550 1St Ave, New York, NY 10016 USA

[8] Columbia Univ, Dept Pharmacol, New York, NY USA

[9] UCL, Div Med, Gower St, London WC1E 6BT, England

[10] Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA

来源：

HIPPOCAMPUS | 2016年 / 26卷 / 06期

关键词：

adult neurogenesis; dentate gyrus; hippocampus; granule cells; inhibition; optogenetics; interneurons; MOSSY FIBER SYNAPSES; GRANULE CELLS; PATTERN SEPARATION; HIPPOCAMPAL NEUROGENESIS; ENVIRONMENTAL ENRICHMENT; RAT HIPPOCAMPUS; CRITICAL PERIOD; IN-VITRO; INTERNEURONS; EXPERIENCE;

D O I：

10.1002/hipo.22557

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Robust incorporation of new principal cells into preexisting circuitry in the adult mammalian brain is unique to the hippocampal dentate gyrus (DG). We asked if adult-born granule cells (GCs) might act to regulate processing within the DG by modulating the substantially more abundant mature GCs. Optogenetic stimulation of a cohort of young adult-born GCs (0 to 7 weeks post-mitosis) revealed that these cells activate local GABAergic interneurons to evoke strong inhibitory input to mature GCs. Natural manipulation of neurogenesis by aging-to decrease it-and housing in an enriched environment-to increase it-strongly affected the levels of inhibition. We also demonstrated that elevating activity in adult-born GCs in awake behaving animals reduced the overall number of mature GCs activated by exploration. These data suggest that inhibitory modulation of mature GCs may be an important function of adult-born hippocampal neurons. (C) 2015 Wiley Periodicals, Inc.

引用

页码：763 / 778

页数：16

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