Constructing Cross-Linked Nanofibrous Scaffold via Dual-Enzyme-Instructed Hierarchical Assembly

被引：7

作者：

Zhang, Shijin ^{[1
]}

Cortes, William ^{[1
]}

Zhang, Ye ^{[1
]}

机构：

[1] Okinawa Inst Sci & Technol Grad Univ, Bioinspired Soft Matter Unit, Onna, Okinawa 9040495, Japan

来源：

LANGMUIR | 2020年 / 36卷 / 22期

关键词：

HYDROGELS; PEPTIDES;

D O I：

10.1021/acs.langmuir.0c01023

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To explore the potential of step-by-step assembly in the fabrication of biological materials, we designed and synthesized two peptide-based molecules for enzyme-instructed hierarchical assembly. Upon the treatment of alkaline phosphatase, one molecule undergoes enzyme-instructed self-assembly forming uniformed nanofibers. The other one that can self-assemble into vesicles undergoes enzyme-induced transformation of self-assembly converting vesicles into irregular aggregates upon the treatment of carboxylesterase. Coadministration of two enzymes to a mixture of these two molecules in a stage-by-stage fashion leads to a physically knotted nanofibrous scaffold that is applicable as a nanostructured matrix for cell culture.

引用

页码：6261 / 6267

页数：7

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