Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments

被引：337

作者：

Mourino, Viviana ^{[1
,2
]}

Pablo Cattalini, Juan ^{[1
]}

Boccaccini, Aldo R. ^{[3
]}

机构：

[1] Univ Buenos Aires, Fac Pharm & Biochem, Dept Pharmaceut Technol, RA-1113 Buenos Aires, DF, Argentina

[2] Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina

[3] Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, D-91058 Erlangen, Germany

来源：

JOURNAL OF THE ROYAL SOCIETY INTERFACE | 2012年 / 9卷 / 68期

关键词：

metallic ions; tissue engineering; scaffolds; bone; drug delivery; controlled release; PROTEIN-TYROSINE PHOSPHATASES; OSTEOBLAST-LIKE CELLS; HUMAN ENDOTHELIAL-CELLS; IN-VITRO BIOACTIVITY; DRUG-DELIVERY; ALKALINE-PHOSPHATASE; DISSOLUTION PRODUCTS; GALLIUM NITRATE; GENE-EXPRESSION; TRACE-ELEMENTS;

D O I：

10.1098/rsif.2011.0611

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This article provides an overview on the application of metallic ions in the fields of regenerative medicine and tissue engineering, focusing on their therapeutic applications and the need to design strategies for controlling the release of loaded ions from biomaterial scaffolds. A detailed summary of relevant metallic ions with potential use in tissue engineering approaches is presented. Remaining challenges in the field and directions for future research efforts with focus on the key variables needed to be taken into account when considering the controlled release of metallic ions in tissue engineering therapeutics are also highlighted.

引用

页码：401 / 419

页数：19

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