Amphiphilic comb-like polymers based on poly(oxyethylene)s as drug-delivery carriers

被引：20

作者：

Kim, Ki-Hyun ^{[2
]}

Lee, Jong-Chan ^{[2
]}

Lee, Jonghwi ^{[1
]}

机构：

[1] Chung Ang Univ, Dept Chem Engn & Mat Sci, Seoul 156756, South Korea

[2] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151744, South Korea

来源：

MACROMOLECULAR BIOSCIENCE | 2008年 / 8卷 / 04期

关键词：

drug-delivery systems; micelles; non-linear polymers; particle size distribution; water-soluble polymers;

D O I：

10.1002/mabi.200700161

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Comb-like polymers with biocompatible oxyethylene backbones and amphiphilic side groups were synthesized via polymer-analogous reactions. Using these polymers, indomethacin-loaded polymeric micelles were fabricated with various drug-to-polymer weight ratios using the oil-in-water emulsion technique. In addition, the size, size distribution, CMC, drug-loading content, and entrapment efficiency of the polymeric micelles were analyzed. The volume-weighted diameters of polymeric micelles ranged from 10 to 140 nm and were narrowly distributed for passive targeting drug delivery. The CMCs were lower (approximate to 10(-8) m) than for conventional. surfactants and block copolymers.

引用

页码：339 / 346

页数：8

共 39 条

[1] Amphiphilic block copolymers for drug delivery [J].

Adams, ML ;

Lavasanifar, A ;

Kwon, GS .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 92 (07) :1343-1355

[2] MICELLIZATION OF POLY(ETHYLENE OXIDE)-POLY(PROPYLENE OXIDE)-POLY(ETHYLENE OXIDE) TRIBLOCK COPOLYMERS IN AQUEOUS-SOLUTIONS - THERMODYNAMICS OF COPOLYMER ASSOCIATION [J].

ALEXANDRIDIS, P ;

HOLZWARTH, JF ;

HATTON, TA .

MACROMOLECULES, 1994, 27 (09) :2414-2425

[3] Nano-engineering block copolymer aggregates for drug delivery [J].

Allen, C ;

Maysinger, D ;

Eisenberg, A .

COLLOIDS AND SURFACES B-BIOINTERFACES, 1999, 16 (1-4) :3-27

[4] Drug delivery systems: Entering the mainstream [J].

Allen, TM ;

Cullis, PR .

SCIENCE, 2004, 303 (5665) :1818-1822

[5] MICELLIZATION IN BLOCK POLYELECTROLYTE SOLUTIONS .2. FLUORESCENCE STUDY OF THE CRITICAL MICELLE CONCENTRATION AS A FUNCTION OF SOLUBLE BLOCK LENGTH AND SALT CONCENTRATION [J].

ASTAFIEVA, I ;

KHOUGAZ, K ;

EISENBERG, A .

MACROMOLECULES, 1995, 28 (21) :7127-7134

[6] CRITICAL MICELLIZATION PHENOMENA IN BLOCK POLYELECTROLYTE SOLUTIONS [J].

ASTAFIEVA, I ;

ZHONG, XF ;

EISENBERG, A .

MACROMOLECULES, 1993, 26 (26) :7339-7352

[7] Amphipolar core-shell cylindrical brushes as templates for the formation of gold clusters and nanowires [J].

Djalali, R ;

Li, SY ;

Schmidt, M .

MACROMOLECULES, 2002, 35 (11) :4282-4288

[8] Polymeric micelles based on amphiphilic scorpion-like macromolecules: Novel carriers for water-insoluble drugs [J].

Djordjevic, J ;

Barch, M ;

Uhrich, KE .

PHARMACEUTICAL RESEARCH, 2005, 22 (01) :24-32

[9] Solubility and solubilization properties of non-steroidal anti-inflammatory drugs [J].

Fini, A ;

Fazio, G ;

Feroci, G .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1995, 126 (1-2) :95-102

[10] BIODEGRADABLE LONG-CIRCULATING POLYMERIC NANOSPHERES [J].

GREF, R ;

MINAMITAKE, Y ;

PERACCHIA, MT ;

TRUBETSKOY, V ;

TORCHILIN, V ;

LANGER, R .

SCIENCE, 1994, 263 (5153) :1600-1603

← 1 2 3 4 →