Biomimetic tissues on a chip for drug discovery

被引：283

作者：

Ghaemmaghami, Amir M. ^{[2
]}

Hancock, Matthew J. ^{[1
]}

Harrington, Helen ^{[2
]}

Kaji, Hirokazu ^{[3
]}

Khademhosseini, Ali ^{[1
,4
,5
]}

机构：

[1] Harvard Univ, Ctr Biomed Engn, Dept Med, Brigham & Womens Hosp,Med Sch, Boston, MA 02139 USA

[2] Univ Nottingham, Div Immunol, Sch Mol Med Sci, Queens Med Ctr, Nottingham NG7 2UH, England

[3] Tohoku Univ, Dept Bioengn & Robot, Grad Sch Engn, Sendai, Miyagi 9808579, Japan

[4] MIT, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[5] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

来源：

DRUG DISCOVERY TODAY | 2012年 / 17卷 / 3-4期

基金：

英国生物技术与生命科学研究理事会; 美国国家科学基金会; 美国国家卫生研究院;

关键词：

ON-A-CHIP; INTEGRATED MICROFLUIDIC SYSTEM; IN-VITRO; LUNG-CANCER; STEM-CELLS; CULTURE; DIFFERENTIATION; NETWORKS; PLATFORM; FLOW;

D O I：

10.1016/j.drudis.2011.10.029

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Developing biologically relevant models of human tissues and organs is an important enabling step for disease modeling and drug discovery. Recent advances in tissue engineering, biomaterials and microfluidics have led to the development of microscale functional units of such models also referred to as 'organs on a chip'. In this review, we provide an overview of key enabling technologies and highlight the wealth of recent work regarding on-chip tissue models. In addition, we discuss the current challenges and future directions of organ-on-chip development.

引用

页码：173 / 181

页数：9

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