Peptidic foldamers: ramping up diversity

被引：424

作者：

Martinek, Tamas A. ^{[1
]}

Fueloep, Ferenc ^{[1
]}

机构：

[1] Univ Szeged, Inst Pharmaceut Chem, H-6720 Szeged, Hungary

来源：

CHEMICAL SOCIETY REVIEWS | 2012年 / 41卷 / 02期

关键词：

BETA-AMINO ACIDS; DE-NOVO DESIGN; EFFECTIVE SIMULATION PROTOCOLS; PROTEINOGENIC SIDE-CHAINS; HELICAL SECONDARY STRUCTURES; MIXED ALPHA/BETA-PEPTIDES; MODEL SYNTHETIC FOLDAMERS; PARALLEL SHEET STRUCTURE; HYDROGEN-BONDED RINGS; GCN4; LEUCINE-ZIPPER;

D O I：

10.1039/c1cs15097a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Non-natural folded polymers (foldamers) display considerable versatility, and the design of such molecules is of great current interest. In this respect, peptidic foldamers are perhaps the best-characterized systems, as they populate a number of residue-controlled secondary structures, which have found various biological applications and have also led to the creation of nanostructured materials. This critical review covers recent developments related to diverse building blocks and modern foldamer design principles, such as the stereochemical patterning methods. The recent achievements concerning tertiary/quaternary structures and the self-assembling foldameric nanostructures are also addressed (176 references).

引用

页码：687 / 702

页数：16

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