Improved Detectability of Plasmodium falciparum Clones with Repeated Sampling in Incident and Chronic Infections in Burkina Faso

被引：4

作者：

Barry, Aissata ^{[1
,2
,3
]}

Awandu, Shehu S. ^{[2
,3
]}

Tiono, Alfred B. ^{[1
]}

Grignard, Lynn ^{[4
]}

Bousema, Teun ^{[2
,3
]}

Collins, Katharine A. ^{[2
,3
]}

机构：

[1] Minist Sante, Ctr Natl Rech & Format Paludisme CNRFP, Ouagadougou, Burkina Faso

[2] Radboud Univ Nijmegen Med Ctr, Dept Med Microbiol, Geert Grootepl Zuid 26-28, NL-6525 GA Nijmegen, Netherlands

[3] Radboud Univ Nijmegen Med Ctr, Radboud Ctr Infect Dis, Nijmegen, Netherlands

[4] London Sch Hyg & Trop Med, Dept Immunol & Infect, London, England

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2022年 / 106卷 / 02期

基金：

欧洲研究理事会; 比尔及梅琳达.盖茨基金会;

关键词：

MALARIA PARASITES;

D O I：

10.4269/ajtmh.21-0493

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We evaluated the detectability of Plasmodium falciparum clones when assessed on 3 consecutive days in incident and chronic infections in naturally exposed children living in an area of intense malaria transmission in Burkina Faso. The median number of clones by merozoite surface protein 2 (MSP2) genotyping was 3 (interquartile range [IQR] 2-5) in incident infections compared with 6 (IQR 4-8) in chronic infections (P, 0.0001). When all clones detected on days 1-3 were considered as true complexity of infection, sampling on day 1 detected only 69.4% (109/157) or 68.3% (228/334) of all clones in incident and chronic infections, respectively. Our findings demonstrate that a large proportion of clones are missed by single time-point sampling. In addition, because of the high complexity of infection early in incident infections, our data suggest many infections may be caused by genetically complex inocula.

引用

页码：664 / 666

页数：3

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