Pheromone signalling and polarized morphogenesis in yeast

被引：188
作者：
Leberer, E
Thomas, DY
Whiteway, M
机构：
[1] MCGILL UNIV,DEPT MED,MONTREAL,PQ,CANADA
[2] MCGILL UNIV,DEPT BIOL,MONTREAL,PQ,CANADA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 01期
关键词：
D O I：
10.1016/S0959-437X(97)80110-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Yeast cells respond to mating pheromones by activating a signal transduction pathway involving a seven transmembrane receptor/G protein complex linked to a mitogen-activated protein kinase module. Regulation of the G protein signal is controlled by the receptor and Sst2p; Sst2p may function as a GTPase-activating protein for the G protein ct subunit. The Ste20 kinase acts in the linkage between the G protein and the MAP kinase module. Experiments suggest that binding of the Rho-like GTPase Cdc42p to Ste20p is not required for the mating response, yet is needed for the pseudohyphal growth response which involves many of the same kinases.
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页码：59 / 66
页数：8
相关论文
共 60 条
[1]  
Akada R, 1996, GENETICS, V143, P103
[2]   GAIP and RGS4 are GTPase-activating proteins for the G(i) subfamily of G protein alpha subunits [J].
Berman, DM ;
Wilkie, TM ;
Gilman, AG .
CELL, 1996, 86 (03) :445-452
[3]   MUTATIONS THAT ALTER THE 3RD CYTOPLASMIC LOOP OF THE A-FACTOR RECEPTOR LEAD TO A CONSTITUTIVE AND HYPERSENSITIVE PHENOTYPE [J].
BOONE, C ;
DAVIS, NG ;
SPRAGUE, GF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :9921-9925
[4]  
Bukusoglu G, 1996, MOL CELL BIOL, V16, P4818
[5]   A CONSERVED BINDING MOTIF DEFINES NUMEROUS CANDIDATE TARGET PROTEINS FOR BOTH CDC42 AND RAC GTPASES [J].
BURBELO, PD ;
DRECHSEL, D ;
HALL, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (49) :29071-29074
[6]   Generation of cell polarity in yeast [J].
Chant, J .
CURRENT OPINION IN CELL BIOLOGY, 1996, 8 (04) :557-565
[7]  
Chen QJ, 1996, MOL CELL BIOL, V16, P247
[8]   THE SMALL GTP-BINDING PROTEINS RAC1 AND CDC42 REGULATE THE ACTIVITY OF THE JNK/SAPK SIGNALING PATHWAY [J].
COSO, OA ;
CHIARIELLO, M ;
YU, JC ;
TERAMOTO, H ;
CRESPO, P ;
XU, NG ;
MIKI, T ;
GUTKIND, JS .
CELL, 1995, 81 (07) :1137-1146
[9]   STE20-LIKE PROTEIN-KINASES ARE REQUIRED FOR NORMAL LOCALIZATION OF CELL-GROWTH AND FOR CYTOKINESIS IN BUDDING YEAST [J].
CVRCKOVA, F ;
DEVIRGILIO, C ;
MANSER, E ;
PRINGLE, JR ;
NASMYTH, K .
GENES & DEVELOPMENT, 1995, 9 (15) :1817-1830
[10]   GAIP, A PROTEIN THAT SPECIFICALLY INTERACTS WITH THE TRIMERIC G-PROTEIN G-ALPHA(I3), IS A MEMBER OF A PROTEIN FAMILY WITH A HIGHLY CONSERVED CORE DOMAIN [J].
DEVRIES, L ;
MOUSLI, M ;
WURMSER, A ;
FARQUHAR, MG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (25) :11916-11920
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