Cats and Apples: Semantic Fluency Performance for Living Things Identifies Patients with Very Early Alzheimer's Disease

被引：5

作者：

Krumm, Sabine ^{[1
,2
]}

Berres, Manfred ^{[3
]}

Kivisaari, Sasa L. ^{[4
]}

Monsch, Andreas U. ^{[1
,2
,5
]}

Reinhardt, Julia ^{[6
,7
]}

Blatow, Maria ^{[6
]}

Kressig, Reto W. ^{[1
,2
]}

Taylor, Kirsten, I ^{[5
,8
]}

机构：

[1] Univ Dept Geriatr Med FELIX PLATTER, CH-4056 Basel, Switzerland

[2] Univ Basel, Fac Med, Basel, Switzerland

[3] Univ Appl Sci Koblenz, Dept Math & Technol, Remagen, Germany

[4] Aalto Univ, Dept Neurosci & Biomed Engn, Sch Sci, Aalto, Finland

[5] Univ Basel, Fac Psychol, Basel, Switzerland

[6] Univ Zurich, Univ Hosp Zurich, Clin Neurosci Ctr, Dept Neuroradiol, Zurich, Switzerland

[7] Univ Basel, Univ Hosp Basel, Dept Radiol, Div Diagnost & Intervent Neuroradiol, Basel, Switzerland

[8] F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Roche Pharma Res & Early Dev, Biomarkers & Translat Technol,Neurosci & Rare Dis, Basel, Switzerland

来源：

ARCHIVES OF CLINICAL NEUROPSYCHOLOGY | 2021年 / 36卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

Alzheimer's disease; Fluency (verbal/nonverbal); Assessment; Dementia; Mild cognitive impairment; PERIRHINAL CORTEX; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; RECOMMENDATIONS; IMPAIRMENT; DEMENTIA; MEMORY;

D O I：

10.1093/arclin/acaa109

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Objective: Reduced semantic memory performance is a known neuropsychological marker of very early Alzheimer's disease (AD), but the task format that best predicts disease status is an open question. The present study aimed to identify the semantic fluency task and measure that best discriminates early-stage AD patients (PATs) from cognitively healthy controls. Method: Semantic fluency performance for animals, fruits, tools, and vehicles was assessed in 70 early-stage AD PATs and 67 cognitively healthy participants. Logistic regressions and receiver operating characteristics were calculated for five total score semantic fluency measures. Results: Compared with all other measures, living things (i.e., total correct animals + total correct fruits) achieved highest z-statistics, highest area under the curve and smallest difference between the upper and lower 95% confidence intervals. Conclusion: Living things total correct is a powerful tool to detect the earliest signs of incipient AD.

引用

页码：838 / 843

页数：6

共 25 条

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