Marine biomaterials: Biomimetic and pharmacological potential of cultivated Aplysina aerophoba marine demosponge

被引：54

作者：

Binnewerg, Bjoern ^{[1
]}

Schubert, Mario ^{[1
]}

Voronkina, Alona ^{[2
]}

Muzychka, Liubov ^{[3
]}

Wysokowski, Marcin ^{[4
,5
]}

Petrenko, Iaroslav ^{[5
]}

Djurovic, Mirko ^{[6
]}

Kovalchuk, Valentine ^{[7
]}

Tsurkan, Mikhail ^{[8
]}

Martinovic, Rajko ^{[6
]}

Bechmann, Nicole ^{[9
]}

Fursov, Andriy ^{[5
]}

Ivanenko, Viatcheslav N. ^{[10
]}

Tabachnick, Konstantin R. ^{[11
,12
]}

Smolii, Oleg B. ^{[3
]}

Joseph, Yvonne ^{[5
]}

Giovine, Marco ^{[13
]}

Bornstein, Stefan R. ^{[14
,15
]}

Stelling, Allison L. ^{[16
]}

Tunger, Antje ^{[17
,18
]}

Schmitz, Marc ^{[17
,18
]}

Taniya, Olga S. ^{[19
,20
]}

Kovalev, Igor S. ^{[19
]}

Zyryanov, Grigory, V ^{[19
,20
]}

Guan, Kaomei ^{[1
]}

Ehrlich, Hermann ^{[5
]}

机构：

[1] Tech Univ Dresden, Inst Pharmacol & Toxicol, D-01307 Dresden, Germany

[2] Natl Pirogov Mem Med Univ, Dept Pharm, UA-21018 Vinnytsya, Ukraine

[3] Natl Acad Sci Ukraine, VP Kukhar Inst Bioorgan Chem & Petrochem, UA-02094 Kiev, Ukraine

[4] Poznan Univ Tech, Fac Chem Technol, Inst Chem Technol & Engn, PL-60965 Poznan, Poland

[5] Tech Univ Bergakad Freiberg, Inst Elect & Sensor Mat, D-09599 Freiberg, Germany

[6] Univ Montenegro, Inst Marine Biol, Kotor 85330, Montenegro

[7] Natl Pirogov Mem Med Univ, Dept Microbiol, UA-21018 Vinnytsya, Ukraine

[8] Leibniz Inst Polymer Res Dresden, D-01069 Dresden, Germany

[9] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Fac Med Carl Gustav Carus, Inst Clin Chem & Lab Med, D-01307 Dresden, Germany

[10] Lomonosov Moscow State Univ, Biol Fac, Dept Invertebrate Zool, Moscow 119992, Russia

[11] Russian Acad Sci, PP Shirshov Inst Oceanol, Moscow 117997, Russia

[12] Int Inst Biomineral GmbH, D-09599 Freiberg, Germany

[13] Univ Genoa, Dept Sci Earth Environm & Life, I-16132 Genoa, Italy

[14] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Internal Med 3, D-01307 Dresden, Germany

[15] Kings Coll London, Diabet & Nutr Sci Div, London WC2R 2LS, England

[16] Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA

[17] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Natl Ctr Tumor Dis, D-01307 Dresden, Germany

[18] Tech Univ Dresden, Fac Med Carl Gustav Carus, Inst Immunol, D-01307 Dresden, Germany

[19] Ural Fed Univ, Dept Organ & Biomol Chem, Chem Engn Inst, Ekaterinburg 620002, Russia

[20] Russian Acad Sci, Postovsky Inst Organ Synth, Ural Branch, Ekaterinburg 620219, Russia

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2020年 / 109卷

关键词：

Marine biomaterials; Chitin; Cell culture; Tissue engineering; Cardiomyocytes; Aeroplysinin-1; CHITIN-BASED SCAFFOLDS; VERONGIDA SPONGES; SECONDARY METABOLITE; BROMINATED COMPOUNDS; CYTOTOXIC ACTIVITY; CELLS; AEROPLYSININ-1; SKELETON; MODEL; BASTA;

D O I：

10.1016/j.msec.2019.110566

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Marine demosponges of the Verongiida order are considered a gold-mine for bioinspired materials science and marine pharmacology. The aim of this work was to simultaneously isolate selected bromotyrosines and unique chitinous structures from A. aerophoba and to propose these molecules and biomaterials for possible application as antibacterial and antitumor compounds and as ready-to-use scaffolds for cultivation of cardiomyocytes, respectively. Among the extracted bromotyrosines, the attention has been focused on aeroplysinin-1 that showed interesting unexpected growth inhibition properties for some Gram-negative clinical multi-resistant bacterial strains, such as A. baumannii and K. pneumoniae, and on aeroplysinin-1 and on isofistularin-3 for their antitumorigenic activity. For both compounds, the effects are cell line dependent, with significant growth inhibition activity on the neuroblastoma cell line SH-SY5Y by aeroplysinin-1 and on breast cancer cell line MCF-7 by isofistularin-3. In this study, we also compared the cultivation of human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) on the A. aerophoba chitinous scaffolds, in comparison to chitin structures that were pre-coated with Geltrex (TM), an extracellular matrix mimetic which is used to enhance iPSC-CM adhesion. The iPSC-CMs on uncoated and pure chitin structures started contracting 24 h after seeding, with comparable behaviour observed on Geltrex-coated cell culture plates, confirming the biocompatibility of the sponge biomaterial with this cell type. The advantage of A. aerophoba is that this source organism does not need to be collected in large quantities to supply the necessary amount for further pre-clinical studies before chemical synthesis of the active compounds will be available. A preliminary analysis of marine sponge bioeconomy as a perspective direction for application of biomaterials and secondary bioactive metabolites has been finally performed for the first time.

引用

页数：12

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