Glyoxylamide-based self-assembly hydrogels for sustained ciprofloxacin delivery

被引：17

作者：

Aldilla, Vina R. ^{[1
]}

Martin, Adam D. ^{[1
,2
,3
]}

Nizalapur, Shashidhar ^{[1
]}

Marjo, Christopher E. ^{[4
]}

Rich, Anne M. ^{[4
]}

Ho, Kitty K. K. ^{[1
]}

Ittner, Lars M. ^{[5
,6
]}

Black, David StC. ^{[1
]}

Thordarson, Pall ^{[1
,2
,3
]}

Kumar, Naresh ^{[1
,2
,3
]}

机构：

[1] UNSW, Sch Chem, Sydney, NSW 2052, Australia

[2] Univ New South Wales, Australian Ctr Nanomed, Sydney, NSW 2052, Australia

[3] Univ New South Wales, ARC Ctr Excellence Convergent Bionano Sci & Techn, Sydney, NSW 2052, Australia

[4] UNSW, Mark Wainwright Analyt Ctr, Sydney, NSW 2052, Australia

[5] UNSW, Sch Med Sci, Dementia Res Unit, Sydney, NSW 2052, Australia

[6] Macquarie Univ, Fac Med & Hlth Sci, Dementia Res Ctr, N Ryde, NSW 2109, Australia

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2018年 / 6卷 / 38期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

DIPHENYLALANINE PEPTIDE NANOTUBES; DRUG-DELIVERY; SUPRAMOLECULAR HYDROGEL; POTENTIAL APPLICATION; INJECTABLE HYDROGEL; DESIGN; ANTIBIOTICS; TRIPEPTIDE; QUINOLONE; CHITOSAN;

D O I：

10.1039/c8tb01290c

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

In this study, we report the synthesis of glyoxylamide peptide-mimics as self-assembled gels with well-defined molecular structures for topical delivery of ciprofloxacin (CIP). The glyoxylamide peptide mimics successfully formed hydrogels with critical gel concentrations of 0.02-0.08% (w/v). The mechanical strength, secondary structure, and fiber morphology of these hydrogels can be modulated by varying the N-substituent of the ring-opened isatins. The synthesised hydrogel exhibited a high loading capacity of CIP (40% (w/w)) and a sustained release profile. The CIP-loaded hydrogels were able to release CIP for more than 15 days and the released solution was shown to retain activity against Gram-positive and Gram-negative bacteria. In addition, the hydrogels formed showed low toxicity against Cos7 cells.

引用

页码：6089 / 6098

页数：10

共 68 条

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