Synthesis,Crystal Structure and Biological Activity of Cu(II) and Ag(I) Complexes Involving Nitroimidazole Derivative

The copper(II) and silver(I) complexes [Cu(L)(Ac)(2)](2) (1), [Ag(L)(NO3)]center dot H2O (2) (L=N,N'-dimethyl-5-nitro-2, 2' -biimidazole) has been synthesized. X-ray crystallographic study was used to determine the crystallographic structure of complex 1, which exhibits a five-coordinated dimeric copper-acetato paddle-wheel geometry. Complex 2 was characterized by elemental analysis, UV-Vis, FT-IR, solid fluorescence spectra, thermogravimetric analysis, ESI-MS and conductivity analysis. The structure of complex 2 probably was a two-coordinated mononuclear structural unit of linear configuration. The binding property of L and complexes toward calf thymus DNA (ct-DNA) was figured out via electronic absorption, fluorescence spectra and viscosity measurements. Complex 1 revealed slightly stronger DNA binding capability than 2 and ligand. The antianaerobe activities of L and its complexes were tested by two-fold agar dilution method. The results showed that L displayed favorable activity of anti-anaerobic bacteria against Actinoba. cillus actinomycetem (ATCC 29523) selectively with minimum inhibitory concentrationsof 0.625 similar to 1.25 mu g.mL(-1), even better than the classical anti-anaerobic drug metronidazole. CCDC: 2036599, 1.