Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders

被引：49

作者：

Zou, Yan-Feng ^{[2
]}

Wang, Fang ^{[1
]}

Feng, Xiao-Liang ^{[2
,3
]}

Li, Wen-Fei ^{[4
]}

Tao, Jin-Hui ^{[5
]}

Pan, Fa-Ming ^{[2
]}

Huang, Fen ^{[2
]}

Su, Hong ^{[2
]}

机构：

[1] Anhui Med Univ, Dept Oncol, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China

[2] Anhui Med Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Hefei 230022, Anhui, Peoples R China

[3] Anhui Med Univ, Dept Basic Med Sci, Hefei 230022, Anhui, Peoples R China

[4] 4th Peoples Hosp Hefei, Dept Psychiat, Hefei 230031, Anhui, Peoples R China

[5] Anhui Prov Hosp, Dept Rheumatol, Hefei 230001, Anhui, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2010年 / 484卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Mood disorders; FKBP5; Polymorphism; Treatment response; Meta-analysis; SEQUENCED TREATMENT ALTERNATIVES; TREATMENT-RESISTANT DEPRESSION; ANTIDEPRESSANT TREATMENT; BIPOLAR DISORDER; MAJOR DEPRESSION; RAPID RESPONSE; RATING-SCALE; BURDEN; DEFINITION;

D O I：

10.1016/j.neulet.2010.08.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of our study was to assess the association between FKBP5 gene polymorphisms and treatment response in patients with mood disorders using a meta-analysis Eight separate studies that included data from 2199 subjects were identified. Meta-analysis was performed for three FKBP5 gene polymorphisms (rs1360780, rs3800373, and rs4713916) A significant association of FKBP5 gene rs4713916 polymorphism and response rate was found in patients with mood disorders (Overall. A versus G. OR =1.28. 95%Cl =1 06-1.53, P= 001, GA +AA versus GG: OR= 1 32, 95%Cl = 1.05-1.67, P= 002 Caucasian. A versus G: OR = 1 28, 95%Cl = 1.06-1 55, P= 0 01, GA + AA versus GG: OR =1.33, 95%Cl =1 04-1.70, P= 0 02) However, we did not detect the association between FKBP5 gene rs1360780 and rs3800373 polymorphisms and treatment response in patients with mood disorders (P> 0.05). This meta-analysis demonstrates that treatment response in patients with mood disorders is associated with FKBP5 gene rs4713916 polymorphism, but not rs1360780 and rs3800373 (C) 2010 Elsevier Ireland Ltd All rights reserved

引用

页码：56 / 61

页数：6

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