Gene therapy of established mesothelioma xenografts with recombinant p16INK4a adenovirus

被引：31

作者：

Frizelle, SP

Rubins, JB

Zhou, JX

Curiel, DT

Kratzke, RA ^{[1
]}

机构：

[1] Univ Minnesota, Sch Med, Minneapolis Vet Affairs Med Ctr, Dept Med,Sect Hematol Oncol 111E, Minneapolis, MN 55417 USA

[2] Univ Minnesota, Sch Med, Minneapolis Vet Affairs Med Ctr, Res Serv, Minneapolis, MN 55417 USA

[3] Univ Alabama Birmingham, Gene Therapy Program, Birmingham, AL 35294 USA

[4] Univ Minnesota, Sch Med, Dept Med, Sect Hematol, Minneapolis, MN 55417 USA

[5] Univ Minnesota, Sch Med, Dept Med, Sect Oncol, Minneapolis, MN 55417 USA

[6] Univ Minnesota, Sch Med, Dept Med, Sect Transplant, Minneapolis, MN 55417 USA

来源：

CANCER GENE THERAPY | 2000年 / 7卷 / 11期

关键词：

p16(INK4a); mesothelioma; tumor suppressor; gene therapy; cell cycle;

D O I：

10.1038/sj.cgt.7700241

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The absence of expression of the p16(INK4a) gene product is observed in virtually all mesothelioma tumors and cell lines, whereas wild-type pRB expression is maintained. We have examined the potential therapeutic role of re-expressing the p16(INK4a) gene product in mice with established human mesothelioma xenografts. Experiments using Adp16 treatments in mesothelioma xenografts demonstrated prolonged survival and potential cure following treatment with p16(INK4a)-based gene therapy. These results demonstrate that p16(INK4a) gene transfer may play a therapeutic role in the treatment of mesothelioma.

引用

页码：1421 / 1425

页数：5

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