Decreased Prefrontal Cortical Volume Associated with Increased Bedtime Cortisol in Traumatized Youth

被引：88

作者：

Carrion, Victor G. ^{[1
]}

Weems, Carl F. ^{[2
]}

Richert, Kit ^{[1
]}

Hoffman, Bryce C. ^{[1
]}

Reiss, Allan L. ^{[1
]}

机构：

[1] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

[2] Univ New Orleans, Dept Psychol, New Orleans, LA 70148 USA

来源：

BIOLOGICAL PSYCHIATRY | 2010年 / 68卷 / 05期

关键词：

Child maltreatment; cortisol; developmental traumatology; posttraumatic stress; prefrontal cortex; structural MRI; POSTTRAUMATIC-STRESS-DISORDER; DIURNAL SALIVARY CORTISOL; CHILDREN; CORTEX;

D O I：

10.1016/j.biopsych.2010.05.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: The purpose of this study was, to investigate prefrontal cortex (PFC) volumes in youth with posttraumatic stress symptoms (PTSS) and explore the relationship between cortisol secretion and PFC volumes. Methods: Total brain tissue volumes, segmented areas of the PFC, and diurnal cortisol secretion were examined in a sample of 33 youth aged 10 to 16 years. Cerebral volumes were available fors 45 subjects (30 PTSS and 15 control subjects). Results: Youth with PTSS had significantly decreased total brain tissue and total cerebral gray volumes in comparison with healthy control subjects. While controlling for total cerebral gray volume, the PTSS group demonstrated decreased left ventral and left inferior prefrontal gray volumes. A significant negative association was found between prebedtime cortisol levels and left ventral PFC gray volumes for the full sample. Conclusions: Findings suggest associations between posttraumatic stress and PFC neurodevelopment. Findings also suggest a link between PFC development and cortisol secretion.

引用

页码：491 / 493

页数：3

共 19 条

[1]

Achenbach T.M., 1991, The Child Behavior Check list-1991

[2]

[Anonymous], 1999, WECHSL ABBR SCAL INT

[3]

Bremner JD., 1999, Posttraumatic Stress Disorder: A Comprehensive Text

[4] Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder [J].

Carrion, VG ;

Weems, CF ;

Eliez, S ;

Patwardhan, A ;

Brown, W ;

Ray, RD ;

Reiss, AL .

BIOLOGICAL PSYCHIATRY, 2001, 50 (12) :943-951

[5] Diurnal salivary cortisol in pediatric posttraumatic stress disorder [J].

Carrion, VG ;

Weems, CF ;

Ray, RD ;

Glaser, B ;

Hessl, D ;

Reiss, AL .

BIOLOGICAL PSYCHIATRY, 2002, 51 (07) :575-582

[6] Stress predicts brain changes in children: A pilot longitudinal study on youth stress, posttraumatic stress disorder, and the hippocampus [J].

Carrion, Victor G. ;

Weems, Carl F. ;

Reiss, Allan L. .

PEDIATRICS, 2007, 119 (03) :509-516

[7] Developmental traumatology Part I: Biological stress systems [J].

De Bellis, MD ;

Baum, AS ;

Birmaher, B ;

Keshavan, MS ;

Eccard, CH ;

Boring, AM ;

Jenkins, FJ ;

Ryan, ND .

BIOLOGICAL PSYCHIATRY, 1999, 45 (10) :1259-1270

[8] Brain structures in pediatric maltreatment-related posttraumatic stress disorder: A sociodemographically matched study [J].

De Bellis, MD ;

Keshavan, MS ;

Shifflett, H ;

Iyengar, S ;

Beers, SR ;

Hall, J ;

Moritz, G .

BIOLOGICAL PSYCHIATRY, 2002, 52 (11) :1066-1078

[9] The child PTSD symptom scale: Preliminary examination of its psychometric properties [J].

Foa, EB ;

Johnson, KM ;

Feeny, NC ;

Treadwell, KRH .

JOURNAL OF CLINICAL CHILD PSYCHOLOGY, 2001, 30 (03) :376-384

[10] Schedule for Affective Disorders and Schizophrenia for School-Age Children Present and Lifetime version (K-SADS-PL): Initial reliability and validity data [J].

Kaufman, J ;

Birmaher, B ;

Brent, D ;

Rao, U ;

Flynn, C ;

Moreci, P ;

Williamson, D ;

Ryan, N .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1997, 36 (07) :980-988

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