Ethanol and glycerol green emulsifying solvent for the formation of a Lavandula stoechas essential oil/B-cyclodextrin inclusion complex: mixture design and adulticidal activity against Culex pipiens

被引:16
作者
Ez-zoubi, Amine [1 ]
Zoubi, Yassine Ez [1 ,2 ]
Ramzi, Amal [1 ]
Fadil, Mouhcine [3 ]
Lalami, Abdelhakim El Ouali [1 ,4 ]
Farah, Abdellah [1 ]
机构
[1] Sidi Mohamed Ben Abdellah Univ, Fac Sci & Tech, Lab Appl Organ Chem, Route Imouzzer, Fes, Morocco
[2] Abdelmalek Essaadi Univ, Fac Sci & Tech Al Hoceima, Dept Biol Environm Technol & Valorizat, Bioresources Team, Tetouan, Morocco
[3] Mohammed V Univ Rabat, Ecole Normale Super, Mat Sci Ctr MSC, Physico Chem Lab Inorgan & Organ Mat, Rabat, Morocco
[4] El Ghassani Hosp, Higher Inst Nursing Profess & Hlth Tech Fez, Reg Hlth Directorate Fez Mekne, Fes 30000, Morocco
关键词
Lavandula stoechas; Inclusion complex; B-Cyclodextrin; Mixture design; Insecticidal activity; Culex pipiens; SSP STOECHAS; L; VARIABILITY; ANTIFUNGAL; TERPENES; BEHAVIOR;
D O I
10.1016/j.heliyon.2022.e10204
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The purpose of this study is to investigate the effect of essential oil medium on the inclusion complex of L. stoechas EO in B-cyclodextrin, as well as to examine the impact of the encapsulating action on the adulticidal activity. In line with this, L. stoechas EO was hydrodistilled and determined through GC-MS. Furthermore, the optimization of EO medium was conducted using a binary mixture design of ethanol and glycerol as green emulsifier solvent. Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray powder diffraction and thermog-ravimetric analysis were used to verify the establishment of the IC. The insecticidal effect of the created formulation was evaluated against C. pipiens female mosquitoes. The optimum ethanol: glycerol ratio was 0.73: 0.27, corresponding to 58.86% of encapsulation efficiency. The fumigant test showed that, after 24 h of exposure, L. stoechas EO exerted only 24.56 +/- 1.04%, while the encapsulated oil killed 57.89% of the adult population. At the highest dose (312.5 mu l/L), the encapsulated oil provided the most significant effect on adults (100% mortality after 54 h) compared to non-encapsulated oil (100% mortality after 72 h). The encapsulated form of L. stoechas EO constitutes a promising alternative for the control of mosquitoes that are responsible for human diseases.
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页数:10
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