Phase II study of tivantinib (ARQ 197) and cetuximab in patients with EGFR inhibitor-resistant, MET-High, KRAS wild-type (KRASwt) metastatic colorectal cancer (mCRC)

被引:0
作者
Lorenza, Rimassa [1 ]
Silvia, Bozzarelli [1 ]
Stefano, Cordio [2 ]
Filippo, Pietrantonio [3 ]
Laura, Toppo [4 ]
Sara, Lonardi [5 ]
Alberto, Zaniboni [6 ]
Roberto, Bordonaro [7 ]
Maria, Di Bartolomeo [8 ]
Wanda, Liguigli [4 ]
Vittorina, Zagonel [5 ]
Chiara, Tronconi Maria [1 ]
Luca, Di Tommaso [9 ]
Laura, Giordano [1 ]
Armando, Santoro [1 ]
机构
[1] Ist Clin Humanitas IRCCS, Humanitas Canc Ctr, Rozzano, Italy
[2] Garibaldi Nesima Hosp, Dept Oncol, Catania, Italy
[3] Fdn IRCCS Ist Nazl Tumori, Milan, Italy
[4] Ist Ospitalieri Cremona, Struttura Complessa Oncol, Cremona, Italy
[5] Ist Oncol Veneto IRCCS, Oncol Med 1, Padua, Italy
[6] Fdn Poliambulanza, Brescia, Italy
[7] Osped Garibaldi, Unita Oncol Med, Catania, Italy
[8] Fdn IRCCS Ist Nazl Tumori, Dept Oncol, Milan, Italy
[9] Ist Clin Humanitas IRCCS, Dept Pathol, Rozzano, Italy
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
PD - 028
引用
收藏
页数:1
相关论文
共 50 条
[41]   A phase I/II study of decitabine in combination with panitumumab in patients with wild-type (wt) KRAS metastatic colorectal cancer [J].
I. Garrido-Laguna ;
K. A. McGregor ;
M. Wade ;
J. Weis ;
W. Gilcrease ;
L. Burr ;
R. Soldi ;
L. Jakubowski ;
C. Davidson ;
G. Morrell ;
J. D. Olpin ;
K. Boucher ;
D. Jones ;
S. Sharma .
Investigational New Drugs, 2013, 31 :1257-1264
[42]   Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer [J].
Baker, J. B. ;
Dutta, D. ;
Watson, D. ;
Maddala, T. ;
Munneke, B. M. ;
Shak, S. ;
Rowinsky, E. K. ;
Xu, L-A ;
Harbison, C. T. ;
Clark, E. A. ;
Mauro, D. J. ;
Khambata-Ford, S. .
BRITISH JOURNAL OF CANCER, 2011, 104 (03) :488-495
[43]   Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer [J].
J B Baker ;
D Dutta ;
D Watson ;
T Maddala ;
B M Munneke ;
S Shak ;
E K Rowinsky ;
L-A Xu ;
C T Harbison ;
E A Clark ;
D J Mauro ;
S Khambata-Ford .
British Journal of Cancer, 2011, 104 :488-495
[44]   Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-type metastatic colorectal cancer [J].
Pander, Jan ;
Gelderblom, Hans ;
Antonini, Ninja F. ;
Tol, Jolien ;
van Krieken, Johan H. J. M. ;
van der Straaten, Tahar ;
Punt, Cornelis J. A. ;
Guchelaar, Henk-Jan .
EUROPEAN JOURNAL OF CANCER, 2010, 46 (10) :1829-1834
[45]   EGFR Protein Expression in KRAS Wild-Type Metastatic Colorectal Cancer Is Another Negative Predictive Factor of the Cetuximab Therapy [J].
Uhlyarik, Andrea ;
Piurko, Violetta ;
Papai, Zsuzsanna ;
Raso, Erzsebet ;
Lahm, Erika ;
Kiss, Edina ;
Sikter, Marta ;
Vachaja, Jozsef ;
Kenessey, Istvan ;
Timar, Jozsef .
CANCERS, 2020, 12 (03)
[46]   Phase II study of combination chemotherapy with biweekly cetuximab and irinotecan for wild-type KRAS metastatic colorectal cancer refractory to irinotecan, oxaliplatin, and fluoropyrimidines [J].
Yuki, S. ;
Shitara, K. ;
Yoshida, M. ;
Takahari, D. ;
Utsunomiya, S. ;
Yokota, T. ;
Sato, Y. ;
Tajika, M. ;
Muro, K. .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (04)
[47]   RE: A Randomized Phase II/III Study of Dalotuzumab in Combination With Cetuximab and Irinotecan in Chemorefractory, KRAS Wild-Type, Metastatic Colorectal Cancer RESPONSE [J].
Sclafani, Francesco ;
Cunningham, David ;
Peckitt, Clare ;
Watkins, David .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2016, 108 (03)
[48]   Phase II study of combination chemotherapy with biweekly cetuximab and irinotecan for wild-type KRAS metastatic colorectal cancer refractory to irinotecan, oxaliplatin, and fluoropyrimidines [J].
Kohei Shitara ;
Satoshi Yuki ;
Motoki Yoshida ;
Daisuke Takahari ;
Setsuo Utsunomiya ;
Tomoya Yokota ;
Yozo Sato ;
Yoshitaka Inaba ;
Masahiro Tajika ;
Hiroki Kawai ;
Hidekazu Yamaura ;
Mina Kato ;
Kentaro Yamazaki ;
Yoshito Komatsu ;
Kei Muro .
Investigational New Drugs, 2012, 30 :787-793
[49]   Phase II study of combination chemotherapy with biweekly cetuximab and irinotecan for wild-type KRAS metastatic colorectal cancer refractory to irinotecan, oxaliplatin, and fluoropyrimidines [J].
Shitara, Kohei ;
Yuki, Satoshi ;
Yoshida, Motoki ;
Takahari, Daisuke ;
Utsunomiya, Setsuo ;
Yokota, Tomoya ;
Sato, Yozo ;
Inaba, Yoshitaka ;
Tajika, Masahiro ;
Kawai, Hiroki ;
Yamaura, Hidekazu ;
Kato, Mina ;
Yamazaki, Kentaro ;
Komatsu, Yoshito ;
Muro, Kei .
INVESTIGATIONAL NEW DRUGS, 2012, 30 (02) :787-793
[50]   Efficacy of chemotherapy plus cetuximab according to metastatic site in KRAS wild-type metastatic colorectal cancer (mCRC): Analysis of CRYSTAL and OPUS studies [J].
Kohne, C. ;
Bokemeyer, C. ;
Heeger, S. ;
Sartorius, U. ;
Rougier, P. ;
Van Cutsem, E. .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)