Homogeneous synthesis and characterization of chitosan ethers prepared in aqueous alkali/urea solutions

被引：62
作者：
Cao, Jinfeng
You, Jun
Zhang, Lina
Zhou, Jinping [1 ]
机构：
[1] Wuhan Univ, Minist Educ, Dept Chem, Wuhan 430072, Hubei, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2018年 / 185卷
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
Chitosan ethers; Aqueous alkali/urea solution; Homogeneous synthesis; Reactivity; Degree of substitution; CARBOXYMETHYL CHITOSAN; METHYLATED CHITOSAN; BIOMEDICAL APPLICATIONS; HYDROXYPROPYL CHITOSAN; ANTIBACTERIAL ACTIVITY; HYDROGELS; DERIVATIVES; CELLULOSE; CHITIN; QUATERNIZATION;
D O I：
10.1016/j.carbpol.2018.01.010
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The etherification of chitosan dissolved in aqueous LiOH/KOH/urea solutions was conducted for the first time. The structure and solution properties of the chitosan ethers were characterized using FT-IR, NMR, SEC-LLS, elemental analysis, and zeta-potential measurement. Chitosan ethers with different degrees of substitution (DSs) were obtained by adjusting the molar ratio of the etherifying agent to N-acetylglucosamine unit (AGU) of chitosan. The total DS for methyl chitosan (MCh) increased from 1.17 to 2.25, and trimethyl chitosan (TMCh) was obtained with DSN-trimethyl as high as 0.48. The total DS for carboxymethyl chitosan (CMCh) was in the range 0.75-1.45. Both N-substitution and O-substitution were observed, and the eOH groups at C-6 displayed relative higher reactivity than the -OH groups at C-3. In comparison with the traditional methods and solvents, aqueous alkali/urea solutions proved to be a stable and more homogeneous medium for preparing chitosan ethers with higher DS through a one-step reaction.
引用
收藏
页码：138 / 144
页数：7
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