Oxidative stress and chromium(VI) carcinogenesis

被引:83
作者
Yao, Hua [1 ]
Guo, Lan [2 ]
Jiang, Bing-Hua [2 ]
Luo, Jia [2 ]
Shi, Xianglin [1 ]
机构
[1] Univ Kentucky, Coll Med, Grad Ctr Toxicol, Lexington, KY 40515 USA
[2] W Virginia Univ, Dept Microbiol Immunol & Cell Biol, Mary Babb Randolph Canc Ctr, Morgantown, WV 26506 USA
关键词
Cr(VI); oxidative stress; signal transduction; carcinogenesis;
D O I
10.1615/JEnvironPatholToxicolOncol.v27.i2.10
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Cr(VI)-containing compounds are known carcinogens that are present in industrial settings and in the environment. The biological mechanisms responsible for the initiation and pregression of diseases resulting from exposure to Cr(VI) are not fully understood. In the last two decades, there has been increasing evidence of the correlation between Cr(VI)-induced generation of reactive oxygen species and carcinogenic actions. This article summarizes the current literature on Cr(VI)-induced generation in various chemical and biological systems. This article also covers the relationship between Cr(VI)-induced oxidative stress and activation of transcription factors NF-kappa B, AP-1, p53, and hypoxia-inducible factor 1, regulation of cell cycle, and induction of apoptosis.
引用
收藏
页码:77 / 88
页数:12
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