Methylphenidate and the risk of burn injury among children with attention-deficit/hyperactivity disorder

被引：9

作者：

Chen, Vincent Chin-Hung ^{[1
,2
]}

Yang, Yao-Hsu ^{[3
,4
]}

Kuo, Ting Yu ^{[3
]}

Lu, Mong-Liang ^{[5
,6
,7
,8
]}

Tseng, Wei-Ting ^{[9
]}

Hou, Tsai-Yu ^{[9
]}

Yeh, Jia-Ying ^{[9
]}

Lee, Charles Tzu-Chi ^{[10
]}

Chen, Yi-Lung ^{[11
,12
]}

Lee, Min-Jing ^{[1
,2
]}

Dewey, Michael E. ^{[13
]}

Gossop, Michael ^{[14
]}

机构：

[1] Chang Gung Mem Hosp, Chiayi Branch, Dept Psychiat, Chiayi, Taiwan

[2] Chang Gung Univ, Sch Med, Taoyuan, Taiwan

[3] Chang Gung Mem Hosp, Hlth Informat & Epidemiol Lab, Chiayi, Taiwan

[4] Chang Gung Mem Hosp, Chiayi Branch, Dept Tradit Chinese Med, Chiayi, Taiwan

[5] Wan Fang Hosp, Dept Psychiat, Taipei, Taiwan

[6] Wan Fang Hosp, Psychiat Res Ctr, Taipei, Taiwan

[7] Taipei Med Univ, Taipei, Taiwan

[8] Taipei Med Univ, Sch Med, Dept Psychiat, Coll Med, Taipei, Taiwan

[9] Chang Gung Mem Hosp, Kaohsiung Branch, Dept Psychiat, Chiayi, Taiwan

[10] Natl Taiwan Normal Univ, Dept Hlth Promot & Hlth Educ, Taipei, Taiwan

[11] Asia Univ, Dept Healthcare Adm, Taichung, Taiwan

[12] Asia Univ, Dept Psychol, Taichung, Taiwan

[13] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[14] Kings Coll London, Natl Addict Ctr, Inst Psychiat Psychol & Neurosci, London, England

来源：

EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES | 2020年 / 29卷

关键词：

Attention-deficit; hyperactivity disorder; burn injury; methylphenidate; DEFICIT-HYPERACTIVITY DISORDER; ADOLESCENTS; MEDICATION; ADHD; TAIWAN; TIME;

D O I：

10.1017/S2045796020000608

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Aims Attention-deficit/hyperactivity disorder (ADHD) is associated with a higher risk of burn injury than in the normal population. Nevertheless, the influence of methylphenidate (MPH) on the risk of burn injury remains unclear. This retrospective cohort study analysed the effect of MPH on the risk of burn injury in children with ADHD. Method Data were from Taiwan's National Health Insurance Research Database (NHIRD). The sample comprised individuals younger than 18 years with a diagnosis of ADHD (n= 90 634) in Taiwan's NHIRD between January 1996 and December 2013. We examined the cumulative effect of MPH on burn injury risk using Cox proportional hazards models. We conducted a sensitivity analysis for immortal time bias using a time-dependent Cox model and within-patient comparisons using the self-controlled case series model. Results Children with ADHD taking MPH had a reduced risk of burn injury, with a cumulative duration of treatment dose-related effect, compared with those not taking MPH. Compared with children with ADHD not taking MPH, the adjusted hazard ratio for burn injury was 0.70 in children taking MPH for <90 days (95% confidence interval (CI) 0.64-0.77) and 0.43 in children taking MPH for >= 90 days (95% CI 0.40-0.47), with a 50.8% preventable fraction. The negative association of MPH was replicated in age-stratified analysis using time-dependent Cox regression and self-controlled case series models. Conclusion This study showed that MPH treatment was associated with a lower risk of burn injury in a cumulative duration of treatment dose-related effect manner.

引用

页数：7

共 39 条

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