Ultradian Rhythms in the Transcriptome of Neurospora crassa

被引：13

作者：

Ananthasubramaniam, Bharath ^{[1
,2
]}

Diernfellner, Axel ^{[3
]}

Brunner, Michael ^{[3
]}

Herzel, Hanspeter ^{[1
,2
]}

机构：

[1] Humboldt Univ, Inst Theoret Biol, D-10115 Berlin, Germany

[2] Charite, D-10117 Berlin, Germany

[3] Heidelberg Univ, Biochem Ctr, D-69120 Heidelberg, Germany

来源：

ISCIENCE | 2018年 / 9卷

关键词：

CIRCADIAN-RHYTHMS; REPRESSOR; PROTEIN; GENES; LIGHT; FRQ;

D O I：

10.1016/j.isci.2018.11.012

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In many organisms, the circadian dock drives rhythms in the transcription of clock-controlled genes that can be either circadian (similar to 24-hr period) or ultradian (<24-hr period). Ultradian rhythms with periods that are a fraction of 24 hr are termed harmonics. Several harmonic transcripts were discovered in the mouse liver, but their functional significance remains unclear. Using a model-based analysis, we report for the first time similar to 7-hr third harmonic transcripts in Neurospora crassa, a well-established fungal circadian model organism. Several third harmonic genes are regulated by female fertility 7 (FF-7), whose transcript itself is third harmonic. The knockout of circadian output regulator CSP1 superimposes circadian rhythms on the third harmonic genes, whereas the knockout of stress response regulator MSN1 converts third harmonic rhythms to second harmonic rhythms. The 460 similar to 7-hr genes are co-regulated in two anti-phasic groups in multiple genotypes and include kinases, chromatin remodelers, and homologs of harmonic genes in the mouse liver.

引用

页码：475 / +

页数：23

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