Regioselective Synthesis of 4-Bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide

被引：1

作者：

Bar, Sukanta ^{[1
,2
]}

Martin, Maxwell Israel ^{[2
]}

机构：

[1] Indian Inst Technol Kharagpur, Dept Chem, Kharagpur 721302, W Bengal, India

[2] St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

来源：

MOLBANK | 2021年 / 2021卷 / 04期

关键词：

thiophene; regioselective; n-BuLi; lithiation; THIOPHENE DERIVATIVES; METALATION;

D O I：

10.3390/M1296

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We synthesized 4-bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide by using three successive direct lithiations and a bromination reaction starting from thiophene. All these lithiation reactions were carried out at -78 degrees C to RT over a period of 1 to 24 h based on the reactivity of electrophile. This is a four-step protocol starting from thiophene with an overall yield of 47%.

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页数：5

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