Plasma cytokines and oxidative damage in HIV-positive and HIV-negative adolescents and young adults: A protective role for IL-10?

被引：7

作者：

Stephensen, CB ^{[1
]}

Marquis, GS

Douglas, SD

Wilson, CM

机构：

[1] Univ Calif Davis, USDA ARS, Western Human Nutr Res Ctr, Davis, CA 95616 USA

[2] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA

[3] Iowa State Univ Sci & Technol, Dept Food Sci & Human Nutr, Ames, IA 50011 USA

[4] Univ Penn, Sch Med, Dept Pediat,Childrens Hosp Penn, Div Allergy & Immunol,Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA

[5] Univ Alabama Birmingham, Dept Pediat & Med, Birmingham, AL 35294 USA

来源：

FREE RADICAL RESEARCH | 2005年 / 39卷 / 08期

关键词：

oxidative damage; HIV; malondialdehyde; protein carbonyl; IL-10;

D O I：

10.1080/10715760500164136

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HIV infection causes immune activation that leads to oxidative damage. Proinflammatory cytokines may promote such damage and the regulatory cytokine IL-10 may protect against such damage. To examine the relation of these cytokines to oxidative damage, 67 cases of oxidative damage and 67 matched controls were selected from the reaching for excellence in adolescent health (REACH) study. Subjects were young (15-23 years), largely female (76%), HIV-positive (73%) and black (69%). Proinflammatory cytokines were not significantly associated with oxidative damage but plasma IL-10 had a significant, negative association with oxidative damage. This finding is consistent with a protective role for IL-10 in diminishing oxidative damage during immune activation.

引用

页码：859 / 864

页数：6

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