Meta-analysis of 16 studies of the association of alcohol with colorectal cancer

被引：120

作者：

McNabb, Sarah ^{[1
,2
]}

Harrison, Tabitha A. ^{[1
]}

Albanes, Demetrius ^{[3
]}

Berndt, Sonja I. ^{[4
]}

Brenner, Hermann ^{[5
,6
,7
,8
]}

Caan, Bette J. ^{[9
]}

Campbell, Peter T. ^{[10
]}

Cao, Yin ^{[11
]}

Chang-Claude, Jenny ^{[12
]}

Chan, Andrew ^{[13
,14
,15
]}

Chen, Zhengyi ^{[16
]}

English, Dallas R. ^{[17
,18
]}

Giles, Graham G. ^{[17
,18
]}

Giovannucci, Edward L. ^{[14
,15
,19
,20
]}

Goodman, Phyllis J. ^{[21
]}

Hayes, Richard B. ^{[22
]}

Hoffmeister, Michael ^{[23
]}

Jacobs, Eric J. ^{[10
]}

Joshi, Amit D. ^{[24
,25
]}

Larsson, Susanna C. ^{[26
]}

Le Marchand, Loic ^{[27
]}

Li, Li ^{[28
]}

Lin, Yi ^{[1
]}

Mannisto, Satu ^{[29
]}

Milne, Roger L. ^{[17
,30
]}

Nan, Hongmei ^{[31
,32
]}

Newton, Christina C. ^{[33
]}

Ogino, Shuji ^{[34
,35
,36
,37
]}

Parfrey, Patrick S. ^{[38
]}

Petersen, Paneen S. ^{[39
]}

Potter, John D. ^{[1
,2
,40
]}

Schoen, Robert E. ^{[41
]}

Slattery, Martha L. ^{[42
]}

Su, Yu-Ru ^{[1
]}

Tangen, Catherine M. ^{[43
]}

Tucker, Thomas C. ^{[44
,45
]}

Weinstein, Stephanie J. ^{[4
]}

White, Emily ^{[1
,2
]}

Wolk, Alicja ^{[26
,46
]}

Woods, Michael O. ^{[47
]}

Phipps, Amanda I. ^{[43
]}

Peters, Ulrike ^{[1
,2
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA

[2] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA

[3] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[4] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[5] Deutsch Krebsforschungszentrum, Div Clin Epidemiol & Aging Res, Heidelberg, Germany

[6] German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany

[7] Natl Ctr Tumor Dis NCT, Heidelberg, Germany

[8] German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany

[9] Kaiser Permanente Med Res Program, Div Res, Oakland, CA USA

[10] Amer Canc Soc, Epidemiol Res Program, New York, NY USA

[11] Washington Univ St Louis, Div Publ Hlth Sci, St Louis, MO USA

[12] German Canc Res Ctr, Unit Genet Epidemiol, Heidelberg, Germany

[13] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA

[14] Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA

[15] Harvard Med Sch, Boston, MA 02115 USA

[16] Case Western Reserve Univ, Sch Med, Ctr Community Hlth Integrat, Cleveland, OH USA

[17] Univ Melbourne, Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia

[18] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia

[19] Harvard Sch Publ Hlth, Dept Epidemiol & Nutr, Boston, MA USA

[20] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

[21] Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[22] NYU, Sch Med, Dept Populat, Div Epidemiol, New York, NY USA

[23] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany

[24] Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[25] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[26] Karolinska Inst, Inst Environm Med, Solna, Sweden

[27] Univ Hawaii, Canc Ctr, Epidemiol Program, Honolulu, HI 96822 USA

[28] Univ Virginia, Dept Family Med, Charlottesville, VA USA

[29] Natl Inst Hlth & Welf, Publ Hlth Solut, Helsinki, Finland

[30] Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia

[31] Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Dept Epidemiol, Indianapolis, IN 46204 USA

[32] Indiana Univ, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46204 USA

[33] Amer Canc Soc, Behav & Epidemiol Res Grp, New York, NY USA

[34] Brigham & Womens Hosp, Dept Pathol, Program MPE Mol Pathol Epidemiol, 75 Francis St, Boston, MA 02115 USA

[35] Dana Farber Canc Inst, Dept Oncol Pathol, Boston, MA 02115 USA

[36] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[37] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[38] Mem Univ, Fac Med, Clin Epidemiol Unit, St John, NF, Canada

[39] Fred Hutchinson Canc Res Ctr, 1100 Fairview Ave N M4-B402, Seattle, WA 98109 USA

[40] Massey Univ, Ctr Publ Hlth Res, Wellington, New Zealand

[41] Univ Pittsburgh, Med Ctr, Dept Med & Epidemiol, Hermitage, PA USA

[42] Univ Utah, Dept Internal Med, Hlth Sci Ctr, Salt Lake City, UT 84112 USA

[43] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA

[44] Markey Canc Ctr, Lexington, KY USA

[45] Univ Kentucky, Dept Epidemiol, Lexington, KY USA

[46] Uppsala Univ, Unity Orthoped, Dept Surg Sci, Uppsala, Sweden

[47] Mem Univ Newfoundland, Discipline Genet, St John, NF, Canada

来源：

INTERNATIONAL JOURNAL OF CANCER | 2020年 / 146卷 / 03期

基金：

瑞典研究理事会; 加拿大健康研究院; 英国医学研究理事会; 美国国家卫生研究院;

关键词：

alcohol; colorectal cancer; colon cancer; rectal cancer; INSULIN SENSITIVITY; POOLED ANALYSIS; FAMILY-HISTORY; COLON-CANCER; RISK; CONSUMPTION; DRINKING; DIETARY; GENE; FOLATE;

D O I：

10.1002/ijc.32377

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Alcohol consumption is an established risk factor for colorectal cancer (CRC). However, while studies have consistently reported elevated risk of CRC among heavy drinkers, associations at moderate levels of alcohol consumption are less clear. We conducted a combined analysis of 16 studies of CRC to examine the shape of the alcohol-CRC association, investigate potential effect modifiers of the association, and examine differential effects of alcohol consumption by cancer anatomic site and stage. We collected information on alcohol consumption for 14,276 CRC cases and 15,802 controls from 5 case-control and 11 nested case-control studies of CRC. We compared adjusted logistic regression models with linear and restricted cubic splines to select a model that best fit the association between alcohol consumption and CRC. Study-specific results were pooled using fixed-effects meta-analysis. Compared to non-/occasional drinking (<= 1 g/day), light/moderate drinking (up to 2 drinks/day) was associated with a decreased risk of CRC (odds ratio [OR]: 0.92, 95% confidence interval [CI]: 0.88-0.98, p = 0.005), heavy drinking (2-3 drinks/day) was not significantly associated with CRC risk (OR: 1.11, 95% CI: 0.99-1.24, p = 0.08) and very heavy drinking (more than 3 drinks/day) was associated with a significant increased risk (OR: 1.25, 95% CI: 1.11-1.40, p < 0.001). We observed no evidence of interactions with lifestyle risk factors or of differences by cancer site or stage. These results provide further evidence that there is a J-shaped association between alcohol consumption and CRC risk. This overall pattern was not significantly modified by other CRC risk factors and there was no effect heterogeneity by tumor site or stage.

引用

页码：861 / 873

页数：13

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