Synthesis and Anti-leukemia Activity of 1-Substituted Piperidin-4-one Arylformylhydrazones

被引：0

作者：

Ni, Zhenjie ^{[1
]}

Xue, Sijia ^{[1
]}

Wang, Jing ^{[1
]}

Meng, Weng ^{[1
]}

机构：

[1] Shanghai Normal Univ, Coll Life & Environm Sci, Shanghai 200234, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 31卷 / 02期

关键词：

1-substituted piperidin-4-one; arylformylhydrazone; synthesis; anti-leukemia bioactivity; K562; MIT; LEUKEMIA; GROWTH;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ten novel 1-substituted piperidin-4-one arylformylhydrazones 9a similar to 9j were synthesized with substituted benzylamines or primary amines as raw materials via a series of Michael addition, Dieckmann condensation, hydrolytic decarboxylation reactions and hydrazone formation reactions. Their structures were elucidated and confirmed by H-1 NMR, IR, MS techniques and elemental analysis. The preliminary biologic activity tests indicate that some of the target compounds have good antiproliferative activities against K562 cells and have potential anti-leukemia bioactivity.

引用

页码：222 / 226

页数：5

共 21 条

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