Statin use and risk of nonmelanoma skin cancer: a nationwide study in Denmark

被引：14

作者：

Arnspang, S. ^{[1
]}

Pottegard, A. ^{[1
,2
]}

Friis, S. ^{[3
,4
,5
]}

Clemmensen, O. ^{[6
]}

Andersen, K. E. ^{[7
,8
]}

Hallas, J. ^{[1
,2
]}

Gaist, D. ^{[9
]}

机构：

[1] Univ Southern Denmark, Inst Publ Hlth, DK-5000 Odense C, Denmark

[2] Odense Univ Hosp, Dept Clin Chem & Pharmacol, DK-5000 Odense C, Denmark

[3] Danish Canc Soc Res Ctr, DK-2100 Copenhagen O, Denmark

[4] Aarhus Univ, Fac Hlth, Inst Clin Med, Aarhus, Denmark

[5] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark

[6] Odense Univ Hosp, Dept Clin Pathol, DK-5000 Odense C, Denmark

[7] Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res, Dept Dermatol,Fac Hlth Sci, DK-5000 Odense C, Denmark

[8] Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res, Allergy Ctr,Fac Hlth Sci, DK-5000 Odense C, Denmark

[9] Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res, Dept Neurol,Fac Hlth Sci, DK-5000 Odense C, Denmark

来源：

BRITISH JOURNAL OF CANCER | 2015年 / 112卷 / 01期

关键词：

skin cancer; nonmelanoma; statins; risk; epidemiology; Denmark; SQUAMOUS-CELL CARCINOMA; METAANALYSIS;

D O I：

10.1038/bjc.2014.527

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Evidence is conflicting regarding statin use and risk of basal cell (BCC) and squamous cell skin cancer (SCC). Methods: Using Danish nationwide registries, we identified all patients with incident BCC/SCC during 2005-2009 and matched them to population controls. We computed odds ratios (ORs) for BCC and SCC associated with statin use. Results: We identified 38 484 cases of BCC and 3724 cases of SCC. Statin ever use was associated with ORs of 1.09 (CI: 1.06-1.13) for BCC and 1.01 (CI: 0.91-1.11) for SCC. Conclusions: Statin use was not associated with risk of SCC. Residual confounding plausibly explains the marginally increased risk of BCC.

引用

页码：153 / 156

页数：4

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