FDA-approved poly(ethylene glycol)-protein conjugate drugs

被引：524
|
作者：
Alconcel, Steevens N. S. [2 ,3 ]
Baas, Arnold S. [1 ]
Maynard, Heather D. [2 ,3 ]
机构：
[1] Univ Calif Los Angeles, Med Ctr, Div Cardiol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA
来源：
POLYMER CHEMISTRY | 2011年 / 2卷 / 07期
基金：
美国国家卫生研究院;
关键词：
SINGLE-ADMINISTRATION PEGFILGRASTIM; HORMONE-RECEPTOR ANTAGONIST; CERTOLIZUMAB PEGOL CDP870; CHRONIC HEPATITIS-C; IN-SITU GROWTH; POLYETHYLENE-GLYCOL; PEGINTERFERON ALPHA-2A; RADICAL POLYMERIZATION; COVALENT ATTACHMENT; ADENOSINE-DEAMINASE;
D O I：
10.1039/c1py00034a
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
PEGylation or covalent attachment of poly(ethylene glycol) improves the pharmacokinetic properties of protein drugs. In vivo circulation lifetimes are increased and dosages are decreased, resulting in improved patient quality of life. PEG may be attached to proteins using a variety of different chemical reactions. This review discusses currently available FDA-approved PEGylated protein drugs, their intended use and target, and the PEG attachment chemistry utilized.
引用
收藏
页码：1442 / 1448
页数：7
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