Application of shock waves to rat skin decreases calcitonin gene-related peptide immunoreactivity in dorsal root ganglion neurons

被引:111
作者
Takahashi, N [1 ]
Wada, Y [1 ]
Ohtori, S [1 ]
Saisu, T [1 ]
Moriya, H [1 ]
机构
[1] Chiba Univ, Grad Sch Med, Dept Orthopaed Surg, Chuo Ku, Chiba 5608677, Japan
来源
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2003年 / 107卷 / 02期
关键词
ganglia; spinal; calcitonin gene-related peptide; extracorporeal shock wave; AFFERENT SENSORY NEURONS; PERIPHERAL-NERVE INJURY; THERAPY; REINNERVATION; TENDINITIS; SHOULDER; AXOTOMY;
D O I
10.1016/S1566-0702(03)00134-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
There have been several reports on the use of extracorporeal shock waves in the treatment of pseudarthrosis, calcifying tendinitis, and tendinopathies of the elbow. However, the pathomechanism of pain relief has not been clarified. To investigate the analgesic properties of shock wave application, we analyzed changes in calcitonin gene-related peptide (CGRP)-immunoreactive (ir) dorsal root ganglion (DRG) neurons. In the nontreated group, fluorogold-labeled dorsal root ganglion neurons innervating the most middle foot pad of hind paw were distributed in the L4 and L5 dorsal root ganglia. Of these neurons, 61% were CGRP-ir. However, in the shock wave-treated group, the percentage of FG-labeled CGRP-ir DRG neurons decreased to 18%. These data show that relief of clinical pain after shock wave application may result from reduced CGRP expression in DRG neurons. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:81 / 84
页数:4
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