Individual differences in cerebral blood flow in area 17 predict the time to evaluate visualized letters

被引:68
作者
Kosslyn, SM
Thompson, WL
Kim, IJ
Rauch, SL
Alpert, NM
机构
[1] HARVARD UNIV,CAMBRIDGE,MA 02138
[2] MASSACHUSETTS GEN HOSP,BOSTON,MA 02114
关键词
D O I
10.1162/jocn.1996.8.1.78
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Sixteen subjects closed their eyes and visualized uppercase letters of the alphabet at two sizes, as small as possible or as large as possible while remaining ''visible.'' Subjects evaluated a shape characteristic of each letter (e.g., whether it has any curved lines), and responded as quickly as possible. Cerebral blood flow was normalized to the same value for each subject, and relative blood flow was computed for a set of regions of interest. The mean response time for each subject in the task was regressed onto the blood flow values. Blood flow in area 17 was negatively correlated with response time (r = -0.65), as was blood flow in area 19 (r = -0.66), whereas blood flow in the inferior parietal lobe was positively correlated with response time (r = 0.54). The first two effects persisted even when variance due to the other correlations was removed. These findings suggest that individual differences in the activation of specific brain loci are directly related to performance of tasks that rely on processing in those loci.
引用
收藏
页码:78 / 82
页数:5
相关论文
共 14 条
[1]  
Damasio H., 1993, Society for Neuroscience Abstracts, V19, P1603
[2]   VISUAL ANGLE OF THE MINDS EYE BEFORE AND AFTER UNILATERAL OCCIPITAL LOBECTOMY [J].
FARAH, MJ ;
SOSO, MJ ;
DASHEIFF, RM .
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-HUMAN PERCEPTION AND PERFORMANCE, 1992, 18 (01) :241-246
[3]   COMPARING FUNCTIONAL (PET) IMAGES - THE ASSESSMENT OF SIGNIFICANT CHANGE [J].
FRISTON, KJ ;
FRITH, CD ;
LIDDLE, PF ;
FRACKOWIAK, RSJ .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1991, 11 (04) :690-699
[4]   REGIONAL CEREBRAL BLOOD-FLOW PATTERNS IN VISUAL-IMAGERY [J].
GOLDENBERG, G ;
PODREKA, I ;
STEINER, M ;
WILLMES, K ;
SUESS, E ;
DEECKE, L .
NEUROPSYCHOLOGIA, 1989, 27 (05) :641-&
[5]  
Goldman-Rakic P. S., 1987, Handbook of physiology, the nervous system, higher functions of the brain, P373, DOI [10.1002/cphy.cp010509, DOI 10.1002/CPHY.CP010509]
[6]  
Kosslyn S., 1994, Image and Brain
[7]   TOPOGRAPHICAL REPRESENTATIONS OF MENTAL IMAGES IN PRIMARY VISUAL-CORTEX [J].
KOSSLYN, SM ;
THOMPSON, WL ;
KIM, IJ ;
ALPERT, NM .
NATURE, 1995, 378 (6556) :496-498
[8]   VISUAL MENTAL-IMAGERY ACTIVATES TOPOGRAPHICALLY ORGANIZED VISUAL-CORTEX - PET INVESTIGATIONS [J].
KOSSLYN, SM ;
ALPERT, NM ;
THOMPSON, WL ;
MALJKOVIC, V ;
WEISE, SB ;
CHABRIS, CF ;
HAMILTON, SE ;
RAUCH, SL ;
BUONANNO, FS .
JOURNAL OF COGNITIVE NEUROSCIENCE, 1993, 5 (03) :263-287
[9]   ACTIVATION OF HUMAN PRIMARY VISUAL-CORTEX DURING VISUAL RECALL - A MAGNETIC-RESONANCE-IMAGING STUDY [J].
LEBIHAN, D ;
TURNER, R ;
ZEFFIRO, TA ;
CUENOD, CA ;
JEZZARD, P ;
BONNEROT, V .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :11802-11805
[10]  
MENON R, 1993, FUNCTIONAL MRI BRAIN