Dysfunctional Endothelial Progenitor Cells in Chronic Kidney Disease

被引：73

作者：

Goligorsky, Michael S. ^{[1
]}

Yasuda, Kaoru

Ratliff, Brian

机构：

[1] New York Med Coll, Dept Med, Renal Res Inst, Valhalla, NY 10595 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2010年 / 21卷 / 06期

基金：

美国国家卫生研究院;

关键词：

HEMATOPOIETIC STEM-CELLS; MARROW-DERIVED CELLS; CORONARY-ARTERY-DISEASE; NITRIC-OXIDE SYNTHASE; VASCULAR REPAIR; POSTNATAL NEOVASCULARIZATION; ISCHEMIC-INJURY; MOUSE MODEL; IN-VITRO; MOBILIZATION;

D O I：

10.1681/ASN.2009111119

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Putative endothelial progenitor cells play a role in organ regeneration, and their incompetence may be important in the development of chronic kidney disease. The mechanisms of this incompetence are broad and range from poor mobilization, viability, and engraftment to impaired differentiation into mature endothelial cells. By contrasting the role of endothelial progenitor cells in tissue regeneration with their developing incompetence in chronic kidney disease, we emphasize the importance of designing rational pharmacologic strategies to tackle such incompetence in the broader search for therapies to attenuate chronic disease.

引用

页码：911 / 919

页数：9

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