Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy

被引：13

作者：

Sawamura, Soichiro ^{[1
]}

Kajihara, Ikko ^{[1
]}

Makino, Katsunari ^{[1
]}

Makino, Takamitsu ^{[1
]}

Fukushima, Satoshi ^{[1
]}

Jinnin, Masatoshi ^{[1
]}

Oyama, Bungo ^{[2
]}

Hashimoto, Takashi ^{[3
]}

Ihn, Hironobu ^{[1
]}

机构：

[1] Kumamoto Univ, Fac Life Sci, Dept Dermatol & Plast Surg, 1-1-1 Honjo, Kumamoto 8608556, Japan

[2] Kurume Univ, Dept Dermatol, Sch Med, Kurume, Fukuoka, Japan

[3] Kurume Univ, Inst Cutaneous Cell Biol, Kurume, Fukuoka, Japan

来源：

AUSTRALASIAN JOURNAL OF DERMATOLOGY | 2017年 / 58卷 / 03期

关键词：

chronic thyroiditis; myasthenia gravis; pemphigus foliaceus; systemic lupus erythematosus; thymectomy; AUTOIMMUNE-DISEASES; THYMOMA;

D O I：

10.1111/ajd.12510

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A 65-year-old woman had undergone a thymectomy for thymoma and 1 year after surgery she developed scattered erosive erythema with scaling and crusting. Examination findings exhibited the elevation of anti-dsDNA antibody, anti-desmoglein 1 antibody, anti-acetylcholine receptor antibody and anti-thyroglobulin antibody. A skin biopsy showed intraepidermal blisters containing neutrophils and acantholytic keratinocytes and direct immunofluorescence revealed the deposition of immunoglobulin G in the epidermis and on the basement membrane. These findings indicated the presence of systemic lupus erythematosus (SLE), myasthenia gravis, pemphigus foliaceus and chronic thyroiditis. Only 1% of SLE patients have three other autoimmune diseases according to previous publications. Our case is rare because she suffered four autoimmune diseases after the thymectomy.

引用

页码：E120 / E122

页数：3

共 10 条

[1] Paraneoplastic pemphigus regression after thymoma resection [J].