Oxidative stress is associated with suspected non-alcoholic fatty liver disease and all-cause mortality in the general population

被引：32

作者：

Damba, Turtushikh ^{[1
,2
]}

Bourgonje, Arno R. ^{[1
]}

Abdulle, Amaal E. ^{[3
]}

Pasch, Andreas ^{[4
]}

Sydor, Svenja ^{[5
]}

van den Berg, Eline H. ^{[1
]}

Gansevoort, Ron T. ^{[6
]}

Bakker, Stephan J. L. ^{[6
]}

Blokzijl, Hans ^{[1
]}

Dullaart, Robin P. F. ^{[7
]}

van Goor, Harry ^{[8
]}

Moshage, Han ^{[1
,9
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Gastroenterol & Hepatol, Hanzepl 1, NL-9713 GZ Groningen, Netherlands

[2] Univ Groningen, Mongolian Natl Univ Med Sci, Sch Pharm, Ulaanbaatar, Mongolia

[3] Univ Groningen, Univ Med Ctr Groningen, Div Vasc Med, Dept Internal Med, Groningen, Netherlands

[4] Johannes Kepler Univ Linz, Inst Physiol & Pathophysiol, Linz, Austria

[5] Otto Von Guericke Univ Hosp Magdeburg, Dept Gastroenterol Hepatol & Infect Dis, Magdeburg, Germany

[6] Univ Groningen, Univ Med Ctr Groningen, Div Nephrol, Dept Internal Med, Groningen, Netherlands

[7] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands

[8] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands

[9] Univ Groningen, Univ Med Ctr Groningen, Dept Lab Med, Groningen, Netherlands

来源：

LIVER INTERNATIONAL | 2020年 / 40卷 / 09期

关键词：

fatty liver index FLI; free thiols; NAFLD; oxidative stress; DENSITY-LIPOPROTEIN CHOLESTEROL; HYDROGEN-SULFIDE; RISK-FACTORS; HOMEOSTASIS; NAFLD; ALBUMIN; MARKERS; PLASMA; THIOLS;

D O I：

10.1111/liv.14562

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background & Aims Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation, inflammation and an imbalanced redox homeostasis. We hypothesized that systemic free thiol levels, as a proxy of systemic oxidative stress, are associated with NAFLD. Methods Protein-adjusted serum free thiol concentrations were determined in participants from the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort study (n = 5562). Suspected NAFLD was defined by the Fatty Liver Index (FLI >= 60) and Hepatic Steatosis Index (HSI > 36). Results Protein-adjusted serum free thiols were significantly reduced in subjects with FLI >= 60 (n = 1651). In multivariable logistic regression analyses, protein-adjusted serum free thiols were associated with NAFLD (FLI >= 60) (OR per doubling of concentration: 0.78 [95% CI 0.64-0.96],P = .016) even when adjusted for potential confounding factors, including systolic blood pressure, diabetes, current smoking, use of alcohol and total cholesterol (OR 0.80 [95% CI 0.65-0.99],P = .04). This association lost its significance (OR 0.94 [95% CI 0.73-1.21],P = .65) after additional adjustment for high-sensitive C-reactive protein. Stratified analyses showed significantly differential associations of protein-adjusted serum free thiol concentrations with suspected NAFLD for gender (P < .02), hypertension (P < .001) and hypercholesterolemia (P < .003). Longitudinally, protein-adjusted serum free thiols were significantly associated with the risk of all-cause mortality in subjects with NAFLD (FLI >= 60) (HR 0.27 [95% CI 0.17-0.45],P < .001). Conclusion Protein-adjusted serum free thiol levels are reduced and significantly associated with all-cause mortality in subjects with suspected NAFLD. Quantification of free thiols may be a promising, minimally invasive strategy to improve detection of NAFLD and associated risk of all-cause mortality in the general population.

引用

页码：2148 / 2159

页数：12

共 49 条

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