Endocrine and immune responses to resistance training in prostate cancer patients

被引：72
作者：
Galvao, D. A. [1 ]
Nosaka, K.
Taaffe, D. R. [2 ]
Peake, J. [2 ]
Spry, N. [3 ,4 ]
Suzuki, K. [5 ]
Yamaya, K. [6 ]
McGuigan, M. R.
Kristjanson, L. J. [7 ]
Newton, R. U.
机构：
[1] Edith Cowan Univ, Sch Exercise Biomed & Hlth Sci, Vario Hlth Inst, Joondalup, WA 6027, Australia
[2] Univ Queensland, Sch Human Movement Studies, Brisbane, Qld, Australia
[3] Sir Charles Gairdner Hosp, Dept Radiat Oncol, Nedlands, WA 6009, Australia
[4] Univ Western Australia, Fac Med, Crawley, WA, Australia
[5] Waseda Univ, Fac Human Sci, Consolidated Res Inst Adv Sci & Med Care, Tokorozawa, Saitama, Japan
[6] Oyokyo Kidney Res Inst, Aomori, Japan
[7] Curtin Univ Technol, WA Ctr Canc & Palliat Care, Bentley, WA 6102, Australia
来源：
PROSTATE CANCER AND PROSTATIC DISEASES | 2008年 / 11卷 / 02期
关键词：
androgen antagonists; testosterone; inflammation; exercise;
D O I：
10.1038/sj.pcan.4500991
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This study examined the effect of 20 weeks resistance training on a range of serum hormones and inflammatory markers at rest, and following acute bouts of exercise in prostate cancer patients undergoing androgen deprivation. Ten patients exercised twice weekly at high intensity for several upper and lower-body muscle groups. Neither testosterone nor prostate-specific antigen changed at rest or following an acute bout of exercise. However, serum growth hormone (GH), dehydroepiandrosterone (DHEA), interleukin-6, tumor necrosis factor-alpha and differential blood leukocyte counts increased (P<0.05) following acute exercise. Resistance exercise does not appear to compromise testosterone suppression, and acute elevations in serum GH and DHEA may partly underlie improvements observed in physical function.
引用
收藏
页码：160 / 165
页数：6
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