Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics

被引：172
作者：
Hottiger, Michael O. [1 ]
机构：
[1] Univ Zurich, Inst Vet Biochem & Mol Biol, CH-8057 Zurich, Switzerland
来源：
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 84 | 2015年 / 84卷
关键词：
ARTD; PARP; chromatin; histone; NAD; ADP-ribosylation; PAR; POLY(ADP-RIBOSE) POLYMERASE 1; RIBOSE ACCEPTOR SITES; POLY(ADENOSINE DIPHOSPHATE RIBOSYLATION); PROTEOME-WIDE IDENTIFICATION; NUCLEOSOMAL CORE HISTONES; APOPTOSIS-INDUCING FACTOR; BREAST-CANCER CELLS; DNA-DAMAGE; GLYCOHYDROLASE PARG; GENE-EXPRESSION;
D O I：
10.1146/annurev-biochem-060614-034506
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Protein ADP-ribosylation is an ancient posttranslational modification with high biochemical complexity. It alters the function of modified proteins or provides a scaffold for the recruitment of other proteins and thus regulates several cellular processes. ADP-ribosylation is governed by ADP-ribosyltransferases and a subclass of sirtuins (writers), is sensed by proteins that contain binding modules (readers) that recognize specific parts of the ADP-ribosyl posttranslational modification, and is removed by ADP-ribosylhydrolases (erasers). The large amount of experimental data generated and technical progress made in the last decade have significantly advanced our knowledge of the function of ADP-ribosylation at the molecular level. This review summarizes the current knowledge of nuclear ADP-ribosylation reactions and their role in chromatin plasticity, cell differentiation, and epigenetics and discusses current progress and future perspectives.
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收藏
页码：227 / 263
页数：37
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